Results 71 to 80 of about 1,643,465 (296)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Comment on "Interaction of two solitary waves in quantum electron-positron-ion plasma" [Phys. Plasmas \textbf{18}, 052301 (2011)]

, 2011
Recently, Yan-Xia Xu, et al. in the article Ref. [Phys. Plasmas \textbf{18}, 052301 (2011)] have studied the effects of various plasma parameters on interaction of two ion-acoustic solitary waves in an unmagnetized three-dimensional electron-positron-ion
Chandrasekhar S., Landau L. D., M. Akbari-Moghanjoughi, Manfredi G.   +3 more
core   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Laser-Induced Breakdown Spectroscopy Analysis of Sheet Molding Compound Materials

Energies
Sheet Molding Compound (SMC) materials are extensively utilized as high-voltage insulation materials in electrical equipment. SMC materials are prone to aging after long-term operation.
Hua Shen, Honglin Jian, Haohan Zhen, Lei Yu, Haibin Chen, Tao Tong, Xuhui Cui, Xilin Wang   +7 more
doaj   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Focusing of laser-generated ion beams by a plasma cylinder: similarity theory and the thick lens formula

, 2005
It is shown that plasma-based optics can be used to guide and focus highly divergent laser-generated ion beams. A hollow cylinder is considered, which initially contains a hot electron population.
Baeva, T., Gordienko, S., Pukhov, A.
core   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Parameters and controlling of plasma chemistry [PDF]

The parameters involved in plasma polymerization reactions are examined and the use of these parameters in the control of plasma reactions is dicussed.
Tsuji, O.
core   +1 more source

On production and asymmetric focusing of flat electron beams using rectangular capillary discharge plasmas

, 2017
A method for the asymmetric focusing of electron bunches, based on the active plasma lensing technique is proposed. This method takes advantage of the strong inhomogeneous magnetic field generated inside the capillary discharge plasma to focus the ...
Bagdasarov, G. A., Barber, S. K., Bobrova, N. A., Boldarev, A. S., Bulanov, S. S., Bulanov, S. V., Esarey, E., Gasilov, V. A., Gonsalves, A. J., Kando, M., Korn, G., Leemans, W. P., Levato, T., Margarone, D., Olkhovskaya, O. G., Sasorov, P. V., Schroeder, C. B., van Tilborg, J.   +17 more
core   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source