Results 61 to 70 of about 2,744,172 (310)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Spatial Molecular AlO Temperature Distributions in Laser-Induced Plasma

Atoms, 2019
Spatially resolved, line-of-sight measurements of aluminum monoxide emission spectra in laser ablation plasma are used with Abel inversion techniques to extract radial plasma temperatures.
David M. Surmick, Daryl J. Dagel, Christian G. Parigger   +2 more
doaj   +1 more source

Fluorescence fluctuation analysis of Arabidopsis thaliana somatic embryogenesis receptor-like kinase and brassinosteroid insensitive 1 receptor ologomerization. [PDF]

, 2008
Receptor kinases play a key role in the cellular perception of signals. To verify models for receptor activation through dimerization, an experimental system is required to determine the precise oligomerization status of proteins within living cells ...
Vries, S.C., de, Russinova, Eugenia, Visser, Antonie J.W.G., Shah, K., Vries, S.C., de Vries, Sacco C, Hink, M.A., de Vries, S.C., Shah, Khalid, Hink, Mark A, Visser, A.J.W.G., Russinova, E.T., Visser, Antonie JWG, Hink, Mark A., de Vries, Sacco C., Russinova, E.   +15 more
core   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Emission of Fast Hydrogen Atoms in a Low Density Gas Discharge—The Most “Natural” Mirror Laboratory

Atoms, 2019
In this work, we present a new application for the line shapes of emission induced by reflected hydrogen atoms. Optical properties of the solids in contact with the plasma could be effectively measured at the wavelength of Balmer lines: time-resolved ...
Oleksandr Marchuk, Sven Dickheuer, Stephan Ertmer, Yuri Krasikov, Philippe Mertens, Christian Brandt, Sebastijan Brezinsek, Andrei Goriaev, Mykola Ialovega, Beatrix Göths, Arkadi Kreter, Christian Linsmeier   +11 more
doaj   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Defect Detection in Arc-Welding Processes by Means of the Line-to-Continuum Method and Feature Selection

Sensors, 2009
Plasma optical spectroscopy is widely employed in on-line welding diagnostics. The determination of the plasma electron temperature, which is typically selected as the output monitoring parameter, implies the identification of the atomic emission lines ...
Olga M. Conde, Adolfo Cobo, P. Beatriz Garcia-Allende, Jesus Mirapeix, Jose M. Lopez-Higuera   +4 more
doaj   +1 more source

Mechanistic studies of plasma polymerization [PDF]

, 1995
Plasma polymerization is a solventless method for depositing polymeric layers onto any substrate at room temperature. This technique comprises excitation, fragmentation, and polymerization of precursor molecules by an electrical discharge.
Ryan, Martin Edward
core  

Quantitative analysis of aluminum impurities in zinc alloy by laser-induced breakdown spectroscopy

, 2019
Laser-induced breakdown spectroscopy has been employed for the spectroscopic study of a laser-produced Zn alloy plasma for the analysis of Al impurities in Zn alloy. The laser-produced Zn alloy plasma was generated by a pulsed Nd:YAG laser (105 mJ, 3 ns),
Kim, DE, Oh, KJ, Kim, DW, Yoo, KJ, Park, HK   +4 more
core   +1 more source

Combined information from Raman spectroscopy and optical coherence tomography for enhanced diagnostic accuracy in tissue discrimination [PDF]

, 2014
We thank the UK EPSRC for funding, the CR-UK/EPSRC/MRC/DoH (England) imaging programme, the European Union project FAMOS (FP7 ICT, contract no. 317744) and the European Union project IIIOS (FP7/2007-2013, contract no. 238802).
C. Simon Herrington, Bavishna B. Praveen, Herrington, C.S., Andrew Riches, Bellini, N., Ashok, P.C., Praveen, B.B., Nicola Bellini, Riches, A., Dholakia, K., Praveen C. Ashok, Kishan Dholakia   +11 more
core   +1 more source