Results 301 to 310 of about 1,390,499 (412)

Bilirubin Targeting WNK1 to Alleviate NLRP3‐Mediated Neuroinflammation

Advanced Science, EarlyView.
At physiological concentrations, bilirubin binds to the kinase domain of WNK1, thereby augmenting its activity and facilitating the phosphorylation of downstream SPAK/OSR1. This phosphorylation inhibits KCC2 activity, leading to elevate intracellular chloride levels in neurons.
Linfei Mao, Jiayu Lu, Quanjun Yang, Zhenqi Liu, Cuiping Wu, Bingbing Ke, Kaiyan Su, Haolin Yuan, Yaqi Cui, Yao Wang, Richard Salvi, Guang Yang, Shankai Yin, Feng Liu, Chunyan Li   +14 more
wiley   +1 more source

Editorial: Horizontal Gene Transfer Mediated Bacterial Antibiotic Resistance

Frontiers in Microbiology, 2019
Dongchang Sun, Katy Jeannot, Yonghong Xiao, Charles W. Knapp   +3 more
doaj   +1 more source

Development and validation of optimized lentivirus-like particles for gene editing tool delivery with Gag-Only strategy. [PDF]

Eur J Med Res
Jia J, Hao Y, Zhang L, Cao X, An L, Wang H, Ma Q, Jin X, Ma X.   +8 more
europepmc   +1 more source

Plasmid Art

, 2018
Trabajo presentado en Plasmid Biology 2018, celebrado en Seattle (Estados Unidos) del 05 al 09 de agosto de 2018.
openaire   +1 more source

GABP Promotes Mesangial Cell Proliferation and Renal Fibrosis Through GLI1 in Diabetic Nephropathy

Advanced Science, EarlyView.
GABP is found to promote mesangial cell proliferation and ECM deposition through GLI1, while inhibiting GABP or GLI1 prevents the progression of DN by reducing ECM and fibrosis. The research results indicate that a potential therapeutic approach based on inhibiting mesangial cell proliferation and ECM accumulation can effectively treat DN, while GABP ...
Lei Du, Sijie Liu, Yinfei Lu, Dongxue Ren, Xiujuan Yu, Yue Hu, Tingting Yang, Qun Yang, Jingxian Ming, Jiawei Zhang, Xiaoxing Yin, Qian Lu   +11 more
wiley   +1 more source

Identification of the czc metal efflux operon on a new plasmid type in a Pseudomonas aeruginosa clinical isolate belonging to ST357 O11. [PDF]

J Antimicrob Chemother
Valcek A, Strachinaru DIC, Soentjens P, Stoefs A, Van der Henst C.   +4 more
europepmc   +1 more source

Simple Agarose Gel Electrophoretic Method for the Identification and Characterization of Plasmid Deoxyribonucleic Acid [PDF]

, 1977

openalex   +1 more source

Plasmid incompatibility [PDF]

Microbiological Reviews, 1987
openaire   +2 more sources

Shrimp Virus Regulates ROS Dynamics via the Nrf2 Pathway to Facilitate Viral Replication

Advanced Science, EarlyView.
Viruses manipulate host ROS as a strategy to achieve successful infection. WSSV exploits Nrf2 pathway to maintain ROS homeostasis and establishes a positive feedback loop to facilitate WSSV replication. Wsv220 competitively binds to Keap1 to activate Nrf2. Nrf2 up‐regulates LvG6PDH to produce more NADPH and GSH to eliminate excessive ROS.
Honghui He, Kai Yuan, Junming Pan, Shaoping Weng, Chaozheng Li, Yihong Chen, Jianguo He   +6 more
wiley   +1 more source

Parasitic plasmids are anchored to inactive regions of eukaryotic chromosomes through a nucleosome signal. [PDF]

EMBO J
Girard F, Even A, Thierry A, Ruault M, Meneu L, Larrous P, Garnier M, Adiba S, Taddei A, Koszul R, Cournac A.   +10 more
europepmc   +1 more source