Results 331 to 340 of about 1,390,499 (412)

Polyplex Nanomicelle‐Mediated Pgc‐1α4 mRNA Delivery Via Hydrodynamic Limb Vein Injection Enhances Damage Resistance in Duchenne Muscular Dystrophy Mice

Advanced Science, EarlyView.
This study presents a novel approach for treating Duchenne muscular dystrophy using mRNA encoding PGC‐1α4. Nanomicelle‐delivered Pgc‐1α4 mRNA enhances muscle damage resistance and mitochondrial activity in dystrophic muscles. This study demonstrates the potential of mRNA therapy for neuromuscular diseases like Duchenne muscular dystrophy and highlights
Xuan Du, Hideyuki Nakanishi, Takashi Yamada, Yooksil Sin, Katsura Minegishi, Norio Motohashi, Yoshitsugu Aoki, Keiji Itaka   +7 more
wiley   +1 more source

A Plasmid-Encoded Surface Polysaccharide Partly Blocks <i>Ceduovirus</i> Infection in Lactococci. [PDF]

Int J Mol Sci
Rendueles C, Garay-Novillo JN, Rau MH, Gaspar P, Ruiz-Masó JÁ, Mahony J, Rodríguez A, Barra JL, Del Solar G, Martínez B.   +9 more
europepmc   +1 more source

Geniposidic Acid Targeting FXR “S332 and H447” Mediated Conformational Change to Upregulate CYPs and miR‐19a‐3p to Ameliorate Drug‐Induced Liver Injury

Advanced Science, EarlyView.
Drug abuse exacerbates cholesterol and bile acids burden, causing liver injury. Geniposidic acid targets FXR Ser332 and His447, together with SRC2‐3 recruitment and activated FXR nuclear translocation. Geniposidic acid‐activated FXR can upregulate CYPs to accelerate bile acids clearance and activate miR‐19a‐3p to suppress LXR‐mediated cholesterol ...
Minqi Fan, Yuanhang Xu, Bingxin Wu, Jiachan Long, Caihong Liu, Zuhui Liang, Rong Zhang, Zhongqiu Liu, Caiyan Wang   +8 more
wiley   +1 more source

Determination of Antimicrobial Resistance Megaplasmid-Like pESI Structures Contributing to the Spread of <i>Salmonella</i> Schwarzengrund in Japan. [PDF]

Antibiotics (Basel)
Ishihara K, Someno S, Matsui K, Nakazawa C, Abe T, Harima H, Omatsu T, Ozawa M, Iwabuchi E, Asai T.   +9 more
europepmc   +1 more source

Sulfonamide resistance mechanism in Escherichia coli: R plasmids can determine sulfonamide-resistant dihydropteroate synthases.

, 1975
Elspeth Wise, Martha M. Abou‐Donia
openalex   +1 more source

Inhibition of Aberrant Activated Fibroblast‐Like Synoviocytes in Rheumatoid Arthritis by Leishmania Peptide via the Regulation of Fatty Acid Synthesis Metabolism

Advanced Science, EarlyView.
LACK156‐173 is internalized into RA‐FLSs via CAPN2‐mediated endocytosis and inhibits the aggressive phenotype of RA‐FLSs by restoring dysregulated fatty acid synthesis metabolism mediated by overexpressed FASN. The findings suggest that targeting the restoration of fatty acid metabolism could potentially alleviate synovial invasion and joint damage in ...
Jianling Su, Xuemei Fan, Yaoyao Zou, Guangtao Fu, Shiqi Feng, Xiaoxue Wang, Yongmei Yu, Lin Li, Zhenhua Bian, Rongrong Huang, Linmang Qin, Jiping Chen, Qin Zeng, Kai Yan, Caiyue Gao, Zhexiong Lian, Xin Li, Yang Li   +17 more
wiley   +1 more source

Global emergence of Carbapenem-resistant Hypervirulent Klebsiella pneumoniae driven by an IncFII_K34 KPC-2 plasmid. [PDF]

EBioMedicine
Jiang J, Wang L, Hu Y, Chen X, Li P, Zhang J, Zhang Y, Su J, Xu X, Xiao Y, Liu Z, Yu Y, Gao H, Doi Y, van Duin D, Fowler VG, Chen L, Wang M.   +17 more
europepmc   +1 more source

Synthesis of an R plasmid protein associated with tetracycline resistance is negatively regulated.

, 1976
Huilin Yang, Geoffrey Zubay, Stuart B. Levy   +2 more
openalex   +1 more source

Nanotherapy for Neural Retinal Regeneration

Advanced Science, EarlyView.
Nanotechnology enhances ophthalmic treatments by improving drug delivery and regenerating ocular tissues, combating vision loss from retinal diseases through innovative nano‐systems. This review outlines ocular anatomy, pathology, immune microenvironment, and barriers, detailing nanocarrier characteristics, classification, and preparation methods, and ...
Chuyao Yu, Li Dong, Yujia Lv, Xuhan Shi, Ruiheng Zhang, Wenda Zhou, Haotian Wu, Heyan Li, Yitong Li, Zhou Li, Dan Luo, Wen‐Bin Wei   +11 more
wiley   +1 more source

Recombinant protein expression in <i>Acanthamoeba castellanii</i>. [PDF]

Front Bioeng Biotechnol
Salunke P, Kondabagil K, Karpe YA.
europepmc   +1 more source