Results 351 to 360 of about 1,390,499 (412)

Genetic and phenotypic analysis of the virulence plasmid of a non-Shigatoxigenic enteroaggregative <i>Escherichia coli</i> O104:H4 outbreak strain. [PDF]

Microbiology (Reading)
Whelan R, Cyganek M, Oxley CL, Dickins B, Thomas JC, McVicker G.   +5 more
europepmc   +1 more source

A Novel Gene Synthesis Platform for Designing Functional Protein Polymers

Advanced Science, EarlyView.
A new gene synthesis method consisting of rolling‐circle amplification and seamless cloning facilitates the advanced design of protein polymers with repetitive sequences. This method is more cost‐effective and user‐friendly than conventional methods. Using this method, a library of polymers with different repeat units can be easily constructed.
Toshimasa Homma, Rie Yamamoto, Lily Zuin Ping Ang, Alaa Fehaid, Mitsuhiro Ebara   +4 more
wiley   +1 more source

Understanding the transfer and persistence of antimicrobial resistance in aquaculture using a model teleost gut system. [PDF]

Anim Microbiome
Barcan AS, Humble JL, Kasaragod S, Sajib MSI, Barcan RA, McGinnity P, Welch TJ, Robertson B, Vamanu E, Bacigalupo A, Llewellyn MS, Samsing F.   +11 more
europepmc   +1 more source

Delivery of A Chemically Modified Noncoding RNA Domain Improves Dystrophic Myotube Function

Advanced Science, EarlyView.
CYTOR is a pro‐myogenic ncRNA in skeletal muscle. Here, chemical probing of CYTOR, coupled with functional cellular assays identifies exon 2 as an independent myogenic RNA domain. Chemical engineering of CYTOR exon 2 RNA improves pharmacologic properties, including RNA stability and cell‐autonomous immunogenicity.
Zeinabou Niasse‐Sy, Bo Zhao, Ajda Lenardič, Huyen Thuc Tran Luong, Ori Bar‐Nur, Johan Auwerx, Martin Wohlwend   +6 more
wiley   +1 more source

Genetic editing of primary human dorsal root ganglion neurons using CRISPR-Cas9. [PDF]

Sci Rep
Palomino SM, Gabriel KA, Mwirigi JM, Cervantes A, Horton P, Funk G, Moutal A, Martin LF, Khanna R, Price TJ, Patwardhan A.   +10 more
europepmc   +1 more source

NF2 is Essential for Human Endoderm Development

Advanced Science, EarlyView.
This study demonstrates that NF2, moesin‐ezrin‐radixin like (MERLIN) tumor suppressor (NF2) is essential for human endoderm formation. NF2 knockout human induced pluripotent stem cells fail to form endoderm both in vitro and in vivo due to yes‐associated protein 1 (YAP1) nuclear translocation, redirecting differentiation toward myofibroblast‐like cells.
Minjin Jeong, Dongjun Han, Preetida Bhetariya, D. Bradley Welling, Miodrag Stojkovic, Konstantina M. Stankovic   +5 more
wiley   +1 more source

Geographic divergence of methicillin-resistant <i>Staphylococcus aureus</i> ST5-SCC<i>mec</i>I in the aftermath of a major earthquake and tsunami: impact of a plasmid harboring heavy metal resistance genes. [PDF]

mBio
Martínez JRW, Alcalde-Rico M, Jara-Videla E, Reyes J, Carvajal LP, Rincon S, Ríos R, Diaz L, Quesille-Villalobos A, Riquelme-Neira R, Rivas L, Moustafa AM, Hanson B, Undurraga EA, Olivares-Pacheco J, García P, Araos R, Planet PJ, Arias CA, Munita JM.   +19 more
europepmc   +1 more source

RFWD3 Reprograms Nucleotide Metabolism Through PHGDH to Induce Chemoresistance In Osteosarcoma

Advanced Science, EarlyView.
RFWD3 is identified as a key regulator of cisplatin (DDP) sensitivity in osteosarcoma using a genome‐wide CRISPR screen. RFWD3 promotes PHGDH ubiquitination, enhancing NAD+‐mediated nucleotide biosynthesis. Knocking out RFWD3 sensitized osteosarcoma cells to DDP.
Wenchao Zhang, Chi Yin, Lin Qi, Zhongyue Liu, Ruiling Xu, Chao Tu, Zhihong Li   +6 more
wiley   +1 more source

The h4 coil surface region of human papillomavirus type 58 L1 virus-like particle serves as a potential location for presenting the RG1 epitope peptide. [PDF]

Hum Vaccin Immunother
Wang Z, Zhang T, Xu X.
europepmc   +1 more source

TRAF3IP3 Induces ER Stress‐Mediated Apoptosis with Protective Autophagy to Inhibit Lung Adenocarcinoma Proliferation

Advanced Science, EarlyView.
Schematic diagram of the working model of TRAF3IP3 in the coordination of ER stress and autophagy related apoptosis in lung cancer cells. Abstract TNF receptor‐associated factor 3 interacting protein 3 (TRAF3IP3/T3JAM) exhibits dual roles in cancer progression. While upregulated in most malignancies and critical for immune regulation.
Guang Zhao, Jun Qi, Fang Li, Haotian Ma, Rui Wang, Xiuyi Yu, Yufei Wang, Sida Qin, Jie Wu, Chen Huang, Hong Ren, Boxiang Zhang   +11 more
wiley   +1 more source