Electroporation and LNP-mediated delivery of plasmid DNA-encoded H5N1 influenza virus hemagglutinin support protection against highly pathogenic avian influenza. [PDF]
NPJ VaccinesGary EN +12 more
europepmc +1 more source
Temporal and Cell‐Specific Regulation of Synaptic Homeostasis by the Chromatin Remodeler Chd1
Advanced Science, EarlyView.Chd1, the Drosophila homologue of mammalian CHD2 ‐ a gene linked to autism, epilepsy, and intellectual disability, is required for synaptic homeostatic plasticity. Chd1 in glia is necessary for the rapid induction of synaptic homeostasis, whereas Chd1 in motoneurons, muscle, and glia is critical for long‐term maintenance.
Danielle T. Morency +19 more
wiley +1 more source
Protocol for generating protoplasts of Trichoderma koningiopsis and transformation of plasmid DNA. [PDF]
STAR ProtocJin S, Alberti F.
europepmc +1 more source
Gαi1/3 Is a Novel Regulatory Target for RANKL Signal Transduction and Osteoporosis
Advanced Science, EarlyView.ABSTRACT Osteoporosis, characterized by progressive bone loss and increased fracture risk, is a growing concern as the population ages. Current treatments, though advanced, remain limited, underscoring the necessity for novel therapeutic targets. Recent studies have shown that the immune system plays a key role in osteoporosis, with osteoclasts driving
Chaowen Bai +15 more
wiley +1 more source
Chromatin assembly extracts from Drosophila embryos. [PDF]
, 1994 Becker, Peter B. +2 more
core +1 more source
Advanced Science, EarlyView.RNF213 is characterized as a dual‐functional antiviral effector. It directly mediates the degradation of the influenza A virus nucleoprotein (NP) while simultaneously activating the MDA5‐mediated innate immune signaling pathway. This coordinated response establishes a powerful host defense system against viral infection. ABSTRACT Influenza A virus (IAV)
Haoning Li +5 more
wiley +1 more source
Plasmid DNA-based reverse genetics as a platform for manufacturing of bluetongue vaccine. [PDF]
J VirolMlingo TAM, Theron J, Mokoena NB.
europepmc +1 more source
Creative Biogene is a biotechnology company specializing in custom plasmid DNA production service. With years of experience in service of plasmid DNA production, Creative Biogene can offer customized plasmid services at scales from micrograms to grams using Creative Biogene’s unique and proprietary process.
openaire +1 more source
RETREG1‐Mediated Reticulophagy is Essential for Dendritic Cell Maturation and Function in Sepsis
Advanced Science, EarlyView.Reticulophagy regulator 1 (RETREG1) maintains dendritic cell (DC) maturation and function in early sepsis. Mechanistically, activating transcription factor 6 (ATF6) acts as a direct transcription factor regulating RETREG1 expression in response to sepsis‐induced endoplasmic reticulum (ER) stress.
Ren‐Qi Yao +28 more
wiley +1 more source
Loop-extrusion-mediated plasmid DNA cleavage by the bacterial SMC Wadjet complex. [PDF]
Mol CellPradhan B +5 more
europepmc +1 more source