Biotechnology and Bioengineering, EarlyView.Lifecycle perspective on cell and gene therapy manufacturing challenges and enabling GMP solutions. ABSTRACT Cell and gene therapies (CGTs) are revolutionizing modern medicine; however, making these advanced medicines scalable and readily available to commercial manufacturers worldwide is a major challenge. The number of approved CGT products continues
Rajath Samaga +2 more
wiley +1 more source
pSB3, a member of the 2-micron family of plasmids, replicates and is efficiently partitioned in multiple budding yeast species. [PDF]
G3 (Bethesda)Mereshchuk A, Chew JSK, Dobson MJ.
europepmc +1 more source
ATP control of dynamic P1 ParA-DNA interactions: a key role for the nucleoid in plasmid partition. [PDF]
Mol Microbiol, 2010 Vecchiarelli AG +8 more
europepmc +1 more source
Induction and Enhancement of Bacteriocin Production (Review)
Biotechnology and Bioengineering, EarlyView.ABSTRACT Conventionally, bacteriocins are produced by microorganisms on complex substrates, released as semi‐purified preparations or crude fermentates. These bacteriocin‐containing products often exhibit unsatisfactory purity, low active‐substance content, and high production costs, limiting their commercialization and use. This review aims to analyze
Oksana Knysh, Artur Martynov
wiley +1 more source
The combination of active partitioning and toxin-antitoxin systems is most advantageous for low-copy plasmid fitness. [PDF]
Nat CommunEffe J +5 more
europepmc +1 more source
BMEMat, EarlyView.Engineered bacteria serve as smart, living therapeutics that target tumors, deliver drugs, and remodel immunosuppressive microenvironments. This review highlights their potential to potentiate immunotherapy, radiotherapy, and chemotherapy, offering a promising paradigm for precise and synergistic cancer treatment. Abstract The dynamic interplay between
Haonan Shen +9 more
wiley +1 more source
Morphological signatures of bacteria‐laden drying droplets: A multimodal analysis across host fluids
Droplet, EarlyView.Drying patterns of bacteria‐laden droplets encode concentration‐dependent signatures across three host fluids: serum, urine, and nutrient medium. By integrating time‐evolving texture descriptors, image features, and interpretable multimodal machine learning, this study demonstrates a label‐free approach for extracting information on bacterial ...
Anusuya Pal +6 more
wiley +1 more source
Plasmids serve as vehicles and reservoirs of type VI secretion systems. [PDF]
ISME CommunDel Mar Quiñonero-Coronel M +1 more
europepmc +1 more source
The role of Rho GTPases in facial morphogenesis
Developmental Dynamics, EarlyView.The role of small GTPases, RHOA, RAC1, and CDC42 and pathway mediators is reviewed in the context of embryonic facial development. Lip fusion requires cytoskeletal remodeling during morphogenesis of the facial processes and during lip fusion. Fnm, frontonasal mass; lnp, lateral nasal process; mnp, medial nasal process; mxp, maxillary process; np, nasal
Isra Ibrahim, Joy M. Richman
wiley +1 more source
Epidemiology and antimicrobial resistance trends in <i>Haemophilus parainfluenzae</i> in a tertiary care hospital (2018-2022). [PDF]
Microbiol SpectrSaiz-Escobedo L +13 more
europepmc +1 more source