Results 301 to 310 of about 890,612 (362)

Engineering of an Ancestral McbA with Enhanced Domain Mobility Extends Biocatalytic Amide Synthesis Scope

Advanced Synthesis &Catalysis, EarlyView.
We show how engineered ancestral amide bond synthetases (ABSs) together with cofactor recycling using a single polyphosphate kinase paves the way for chemoenzymatic synthesis of pharmacophores. The figure illustrates how ancestral ABS has a more flexible C‐terminal domain, which is associated with enhanced catalytic performance and expanded amine scope.
Elisabeth Söderberg, Marianne R. Molenaar, Katarzyna Zaczyk, Magnus Johansson, Martin A. Hayes, Per‐Olof Syrén   +5 more
wiley   +1 more source

Horizontal transmission of a multidrug-resistant IncM1 plasmid harbouring blaOXA-48 and blaCTX-M-14b among patient microbiotas. [PDF]

J Antimicrob Chemother
Sierra R, Roch M, Prados J, Nguyen A, Cherkaoui A, Renzi G, Schrenzel J, Harbarth S, Vuilleumier N, Andrey DO.   +9 more
europepmc   +1 more source

Structural Characterization and AI‐Enhanced Modeling of a Broadly Neutralizing Camelid Antibody Against SARS‐CoV‐2 Variants

Advanced Therapeutics, EarlyView.
This study characterizes a camelid antibody (B10) with potent neutralizing activity against SARS‐CoV‐2 Wildtype and Omicron variants. Through binding assays, epitope mapping, pseudovirus neutralization, and AI‐driven modeling, the antibody is shown to target conserved RBD regions in a closed Spike conformation.
Katja Hanack, Urszula Orzeł, Anja Schlör, Sourabh Mehta, Anandi Krishnan, Slawomir Filipek, Rushika Patel, Madhvi Joshi, Markus Hoffmann, Stefan Pöhlmann, Chaitanya Joshi, Dorian Liepmann, Ramasamy Paulmurugan, Venkatesan Renugopalakrishnan   +13 more
wiley   +1 more source

Multiple Buster transposons from hAT superfamily displaying transposition activities in mammal cells. [PDF]

Synth Syst Biotechnol
Guan Z, Wang B, Gao B, Shi S, Wang S, Wu H, Diaby M, Chen C, Wang X, Song C.   +9 more
europepmc   +1 more source

RECKLEEN is a lambda Red/CRISPR-Cas9 based single plasmid platform for enhanced genome editing in Klebsiella pneumoniae. [PDF]

Commun Biol
Elsayed EM, Stukenberg D, Meier D, Schmeck B, Becker A.   +4 more
europepmc   +1 more source

African swine fever virus pB318L suppresses inflammatory response by inhibiting NF-κB activation and NLRP3 inflammasome formation. [PDF]

PLoS Pathog
Liu X, Ye G, Zeng Y, Wu H, Dong S, He X, Zhou Q, Liu H, Zhang Z, Li J, Weng C, Huang L.   +11 more
europepmc   +1 more source

Genomic insights into ST85 and ST158 belonging to recently emerged global clones of multidrug-resistant Acinetobacter baumannii isolates from Egypt: in vitro assessment of repurposed drug-antibiotic combinations. [PDF]

Ann Clin Microbiol Antimicrob
El Far MS, Kassem MA, Edward EA, Evans BA, Baker DJ, Zakaria AS.   +5 more
europepmc   +1 more source

Rectal Carriage of Sequence Type 307 Klebsiella pneumoniae High-Risk Clone Harboring Multiple Carbapenemase Genes in Community Hospitals Gauteng, South Africa. [PDF]

Microbiologyopen
Salvador-Oke KT, Pitout J, Peirano G, Strydom KA, Kingsburgh C, Ehlers M, Kock M.   +6 more
europepmc   +1 more source

Clinical stringent response activation promotes conjugal transfer of staphylococcal resistance plasmids

Deventer AT, Sutherland A, Biernacka D, Johnston PR, Stevens CE, Kaczorowska A, Boraston AB, Hobbs JK.   +7 more
europepmc   +1 more source

From plasmid sequence to process design: A computational analysis of metabolism in the context of plasmid DNA manufacturing

Stratis N, Morbidelli M, Kiparissides A.
europepmc   +1 more source