Results 331 to 340 of about 1,093,625 (405)

Comparative genomic analysis of <i>Latilactobacillus sakei</i> strains provides new insights into their association with different niche adaptations. [PDF]

Microbiology (Reading)
Ito K, Ito Y.
europepmc   +1 more source

Tryptophan Metabolite Indole‐3‐Aldehyde Induces AhR and c‐MYC Degradation to Promote Tumor Immunogenicity

Advanced Science, EarlyView.
Tryptophan metabolite Indole‐3‐aldehyde (I3A) downregulates cytosolic AhR and p‐ERK/c‐MYC proteins, together enhancing STAT3 phosphorylation and tumor immunogenicity. Overexpression of the Trp metabolic enzyme interleukin‐4‐induced gene‐1 (IL4I1) in tumor cells increases intracellular levels of I3A and enhances tumor immunogenicity.
Lei Cui, Zining Wang, Zixuan Guo, Hongxia Zhang, Yongxiang Liu, Huanling Zhang, Huan Jin, Feifei Xu, Xiaojuan Wang, Chunyuan Xie, Hui Guo, Tiantian Wang, Yanxun Lin, Qi Zhao, Penghui Zhou, Jing Tan, Jin‐Xin Bei, Peng Huang, Jinyun Liu, Xiaojun Xia   +19 more
wiley   +1 more source

African swine fever virus MGF505-4R facilitates cGAS degradation through TOLLIP-mediated selective autophagy and inhibits the formation of ISGF3 to evade innate immunity. [PDF]

Vet Res
Yao M, Li P, Li X, Li W, Qian P.
europepmc   +1 more source

Unraveling the Role of MDK‐SDC4 Interaction in Pancreatic Cancer‐Associated New‐Onset Diabetes by Single‐Cell Transcriptomic Analysis

Advanced Science, EarlyView.
Midkine (MDK) is a mediator of the interaction between pancreatic cancer and beta cells. MDK, which originated from pancreatic ductal adenocarcinoma cells, exerted deleterious effects on paraneoplastic beta cells by binding to the SDC4 receptor on the beta cell surface and subsequently downregulating the Ras signaling pathway, thereby impairing insulin
Zengyu Feng, Jianyao Lou, Chuanshuai Lin, Haocheng Yu, Yuheng Tu, Jiali Gong, Xiawei Li, Yulian Wu   +7 more
wiley   +1 more source

Characterization of a <i>Listeria monocytogenes</i> plasmid with antibiotic and stress resistance genes. [PDF]

Microb Genom
Barker CR, Greig DR, Olonade I, Swift C, Crewdson A, Painset A, Pittock N, Rajendram D, Godbole G, Ribeca P.   +9 more
europepmc   +1 more source

EGR1 Promotes Craniofacial Bone Regeneration via Activation of ALPL⁺PDGFD⁺ Periosteal Stem Cells

Advanced Science, EarlyView.
ALPL+PDGFD+ (AP+) cells are distinct calvarial periosteal stem cells (PeSCs) with diminished postnatal activity. EGR1 drives PeSCs development via BMP signaling through its Znf2 domain and activates them via CTNNB1/WNT10B signaling through its Znf2/3 domains.
Yang Li, Dazhuang Lu, Fanqing Xu, Jun Yang, Dong Li, Chenlong Yang, Xin Chen, Xu Wang, Jia Qing, Hui Zhang, Yingfei Zhang, Fuchou Tang, Jie Qiao, Ophir D. Klein, Ping Zhang, Yongsheng Zhou   +15 more
wiley   +1 more source

OriV-Finder: a comprehensive web server for bacterial plasmid replication origin analysis. [PDF]

Nucleic Acids Res
Li Y, Gao F.
europepmc   +1 more source

Genomic evolution and dissemination of non-conjugative virulence plasmid of ST65 carbapenem-resistant and hypervirulent <i>Klebsiella pneumoniae</i> strains in a Chinese hospital. [PDF]

Front Cell Infect Microbiol
Tian D, Zhao M, Liu L, Lu S, Dong H.
europepmc   +1 more source

A simplified two-plasmid system for orthogonal control of mammalian gene expression using light-activated CRISPR effector. [PDF]

BMC Biotechnol
Garimella SS, Minami SA, Khanchandani AN, Abad Santos JC, Schaffer SR, Shah PS.   +5 more
europepmc   +1 more source