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Plasminogen activation and cancer
Thrombosis and Haemostasis, 2005SummaryBreakdown of the extracellular matrix is crucial for cancer invasion and metastasis. It is accomplished by the concerted action of several proteases, including the serine protease plasmin and a number of matrix metalloproteases. The activity of each of these proteases is regulated by an array of activators, inhibitors and cellular receptors ...
Danø, Keld +6 more
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Studies on the kinetics of plasminogen activation by tissue plasminogen activator
Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1982The steady-state rate of plasminogen activation by tissue plasminogen activator has been determined at various plasminogen concentrations. A plasmin substrate method similar to that presented by Christensen and Müllertz (Biochim. Biophys. Acta 480 (1977) 257-281) was used.
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Plasminogen Activators and Angiogenesis
1996The formation of capillaries from preexisting blood vessels (angiogenesis) occurs in a variety of normal and pathological conditions, including organ development, would healing and tumor growth. Angiogenesis requires a strict temporal modulation of opposing cell functions: cell proliferation and migration, and extracellular matrix (ECM) degradation in ...
D. B. Rifkin, P. Mignatti
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Mechanisms of plasminogen activation
Journal of Internal Medicine, 1994The fibrinolytic system consists of an inactive proenzyme, plasminogen, that is converted by plasminogen activators to the active enzyme, plasmin, that degrades fibrin. Two immunologically distinct plasminogen activators have been identified: tissue-type plasminogen activator (t-PA) and urokinase-type plasminogen activator (u-PA).
S. Thorsen +6 more
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New England Journal of Medicine, 1988
TISSUE plasminogen activator (t-PA) is a naturally occurring protein that catalyzes the conversion of the inactive proenzyme plasminogen into the active serine protease plasmin.
John A. Oates +3 more
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TISSUE plasminogen activator (t-PA) is a naturally occurring protein that catalyzes the conversion of the inactive proenzyme plasminogen into the active serine protease plasmin.
John A. Oates +3 more
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Thrombosis Research, 1988
Glu-plasminogen (Glu-plg), Lys-plg and Val442-plg (mini-plg) were activated by urokinase (UK), streptokinase (SK) or tissue plasminogen activator (t-PA). Their activation rates were kinetically analyzed. UK activated Lys-plg with smaller Km and nearly identical Vmax as Glu-plg.
Yoshiaki Sugawara +2 more
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Glu-plasminogen (Glu-plg), Lys-plg and Val442-plg (mini-plg) were activated by urokinase (UK), streptokinase (SK) or tissue plasminogen activator (t-PA). Their activation rates were kinetically analyzed. UK activated Lys-plg with smaller Km and nearly identical Vmax as Glu-plg.
Yoshiaki Sugawara +2 more
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Plasminogen activator inhibitors
Trends in Cardiovascular Medicine, 1991Plasminogen activator inhibitors (PAIs) regulate plasminogen activation in normal and pathologic processes. Plasminogen activator inhibitor 1 (PAI-1) is the major physiologic inhibitor of both tissue-type and urokinase-type plasminogen activators. It is a highly regulated single-chain glycoprotein, whose overexpression in vivo impairs the fibrinolytic ...
David J. Loskutoff, Jacob Schneiderman
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Plasminogen activator and cancer
European Journal of Cancer and Clinical Oncology, 1984Plasminogen activator is a protease which catalyses the conversion of the inactive plasminogen to the active plasmin. Most transformed cell lines and solid tumors produce elevated levels of plasminogen activator compared with nontransformed counterparts. This increased synthesis of plasminogen activator may play a role in tumorigenesis, cancer invasion
P. O'Grady, Michael J. Duffy
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Zymographic Evaluation of Plasminogen Activators and Plasminogen Activator Inhibitors
2004Publisher Summary The plasminogen activator/plasminogen activator inhibitor (PA/PAI) system is of considerable fundamental importance in elucidating the biochemical mechanisms of many physiological and patho-physiological processes. Although many techniques are available to assess the PA/PAI system, including ELISA and molecular assays, fibrin ...
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1986
Fluidity of the blood without hemorrhage is maintained by the physiological equilibrium between the coagulation and fibrinolytic systems, each of which is comprised of intrinsic and extrinsic components. Activators of fibrinogen are compounds whose teleological function is the dissolution of fibrin clots which could potentially upset this hemostatic ...
Burton E. Sobel, Alice K. Robison
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Fluidity of the blood without hemorrhage is maintained by the physiological equilibrium between the coagulation and fibrinolytic systems, each of which is comprised of intrinsic and extrinsic components. Activators of fibrinogen are compounds whose teleological function is the dissolution of fibrin clots which could potentially upset this hemostatic ...
Burton E. Sobel, Alice K. Robison
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