Results 221 to 230 of about 317,079 (354)

Therapeutic Perspectives of SIRT6 Regulation: Computational Analysis of Activation and Inhibition by Bioactive Molecules

open access: yesJournal of Molecular Recognition, Volume 39, Issue 1, January 2026.
ABSTRACT Sirtuin 6 (SIRT6) is an enzyme belonging to the class of nicotinamide adenine dinucleotide (NAD+) dependent histone deacetylases. It has been of interest due to its multivariate biological role and association with aging‐related diseases and metabolic dysfunctions.
Érika Geicianny de Carvalho Matias   +5 more
wiley   +1 more source

Detergents alter the stability and lipid binding properties of the CD1d immunoreceptor

open access: yesProtein Science, Volume 35, Issue 1, January 2026.
Abstract CD1d, a non‐classical immunoreceptor, plays a central role in lipid antigen presentation to a variety of T cell types. Despite the widespread use of detergents to measure and manipulate lipid/CD1d interactions in vitro, in situ, and in vivo, the molecular basis by which detergents influence the stability of CD1d and its lipid binding ...
Uri Z. Miles   +2 more
wiley   +1 more source

Is Toxoplasma gondii‐secreted Protein With an Altered Thrombospondin Repeat (TgSPATR) a Potential Candidate for Immunisation? An Immunoinformatics‐Based Analysis

open access: yesVeterinary Medicine and Science, Volume 12, Issue 1, January 2026.
Toxoplasma gondii‐secreted protein with an altered thrombospondin repeat was computationally characterised as an immunogenic, non‐allergenic protein carrying multiple B‐ and T‐cell epitopes. Structural validation and immune simulation suggest its strong potential as a vaccine candidate against toxoplasmosis.
Masoud Foroutan   +2 more
wiley   +1 more source

Common Molecular Detection of the Neglected Human Malaria Parasite Among Febrile Patients in Southern Regions in Senegal. [PDF]

open access: yesPathogens
Sambe BS   +12 more
europepmc   +1 more source

Energetic and oxidative costs of microfilarial infection: evidence for fitness trade‐offs in male village weavers of the Amurum Forest Reserve

open access: yesWildlife Biology, Volume 2026, Issue 1, January 2026.
Microfilariae contribute to a higher energetic demand that could lead to oxidative damage and reduce hosts' fitness. Yet reports about the energy status and oxidative stress‐defense mechanisms of infected wild birds are rarely documented. We investigated the relationship between microfilariae and the energy status and oxidative damage‐defense ...
Felix A. Andong   +6 more
wiley   +1 more source

Advances in Microbial Diagnostics: Machine Learning and Nanotechnology for Zoonotic Disease Control

open access: yesWIREs Nanomedicine and Nanobiotechnology, Volume 18, Issue 1, January/February 2026.
This review highlights how integrating machine learning with nanotechnology enables enhanced diagnostics, personalized treatments, and the prediction of outbreaks for zoonotic diseases, offering a unified framework to advance global health. ABSTRACT Zoonotic diseases pose significant global health threats, with microbial pathogens, including bacteria ...
Narges Lotfalizadeh   +8 more
wiley   +1 more source

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