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Transfection of Plasmodium falciparum
2012Genetic manipulation of Plasmodium falciparum remains very challenging, mainly due to the parasite genome's high A/T-richness and low transfection efficiency. This chapter includes methods for generating transient and stable transfections by electroporation, allelic replacement with tagged genes, gene deletion, and the analysis of all the above.
Melanie, Rug, Alexander G, Maier
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Plasmodium falciparum: Attenuation by irradiation
Experimental Parasitology, 1983The effect of irradiation on the in vitro growth of Plasmodium falciparum was investigated. The cultured malarial parasites at selected stages of development were exposed to gamma rays and the sensitivity of each stage was determined. The stages most sensitive to irradiation were the ring forms and the early trophozoites; late trophozoites were ...
S, Waki, I, Yonome, M, Suzuki
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Plasmodium falciparum: Isolate-Specific Radiosensitivity
Experimental Parasitology, 2001Geoghegan, D. S., Skinner-Adams, T., and Davis, T. M. E. 2001. Plasmodium falciparum: Isolate-specific radiosensitivity. Experimental Parasitology99, 108–110.
Geoghegan, DS +2 more
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Malabsorption in Plasmodium Falciparum Malaria
The American Journal of Tropical Medicine and Hygiene, 1972Abstract Impaired gastrointestinal function was detected during the acute phase of illness in patients with Plasmodium falciparum malaria. Nine of 11 (82%) had diminished D-xylose absorption, 6 of 10 (60%) had decreased absorption of vitamin B12, and 5 of 11 (45%) had low serum carotene levels.
W W, Karney, M J, Tong
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Mating Patterns of Plasmodium falciparum
Parasitology Today, 1998Recent empirical data have enabled a more informed debate over the extent of clonality in Plasmodium falciparum populations. Oocyst heterozygosity data reveal that the mating structure of malaria populations varies according to the transmission intensity.
R E, Paul, K P, Day
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Adenine metabolism in Plasmodium falciparum
Experimental Parasitology, 2010Plasmodium falciparum lacks the de novo purine biosynthesis pathway and relies entirely on the salvage pathway to meet its purine nucleotide requirements. The entire flux for purine nucleotide biosynthesis in the parasite is believed to be through hypoxanthine guanine phosphoribosyltransferase (HGPRT), with the enzymes, adenosine kinase and adenine ...
Sonali, Mehrotra +3 more
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Codon usage in Plasmodium falciparum
Molecular and Biochemical Parasitology, 1988The codon frequencies used in 7874 codons from 17 sequences of Plasmodium falciparum have been examined. The frequency distribution is markedly biased. A and C occur with similar frequency in all positions but G is predominantly in the first base and T is predominantly in the last position.
A, Saul, D, Battistutta
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Pigment biocrystallization in Plasmodium falciparum
Trends in Parasitology, 2002Malaria parasites catabolize hemoglobin as an important source of amino acids. One consequence of this dependence on hemoglobin degradation is the need for an effective detoxification mechanism for hematin (Fig. 1Fig. 1a,b). To date, the only definitively characterized product of hematin in the parasite is the malaria pigment hemozoin.
Ernst, Hempelmann, Timothy J, Egan
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Intraspecific Variation in Plasmodium Falciparum
The American Journal of Tropical Medicine and Hygiene, 1974Abstract Significant structural differences are observed between the chloroquine-resistant Vietnam (Smith) strain and the chloroquine-sensitive Malaya (Camp-Sadun) strain of Plasmodium falciparum. The Vietnam strain shows subpellicular microtubules in the gametocyte, granular aggregates of the nucleus and enlargement of food vacuoles in the gametocyte ...
M, Aikawa, R A, Ward
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Plasmodium falciparum: Multidrug resistance
Chemical Biology & Drug Design, 2019AbstractMalaria is the most lethal and debilitating disease caused by the protozoan parasite Plasmodium worldwide. The most severe forms of disease and the incidence rates of mortality are associated with P. falciparum infections. With the identification of disease source and symptoms, many chemical entities were developed naturally and synthetically ...
Subhashree Rout, Rajani Kanta Mahapatra
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