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Advancements and Challenges in Developing Malaria Vaccines: Targeting Multiple Stages of the Parasite Life Cycle.

ACS Infectious Diseases, 2023
Malaria, caused by Plasmodium species, remains a major global health concern, causing millions of deaths annually. While the introduction of the RTS,S vaccine has shown promise, there is a pressing need for more effective vaccines due to the emergence of
Rajneesh   +7 more
semanticscholar   +1 more source

Mitochondrial apurinic/apyrimidinic endonuclease Apn1 is not critical for the completion of the Plasmodium berghei life cycle

DNA Repair, 2021
Mitochondrion is an essential organelle in malaria parasite and its DNA must be maintained for optimal function during its complex life cycle. Base excision repair is one of the major pathways by which this is achieved. Apurinic/apyrimidinic (AP) endonucleases are important components of this pathway as they create a nick at the 5'-phosphodiester bond ...
Sunil Kumar Narwal   +3 more
openaire   +3 more sources

Life-Cycle of Plasmodium Relictum Var. Matutinum

The American Journal of Tropical Medicine and Hygiene, 1940
Summary and Conclusions 1.  Exoerythrocytic schizogony has been looked for in 18 cases of infection with Plasmodium relictum var. matutinum, and demonstrated in 9. It has been found both in blood-induced infections and those resulting from the bites of infected mosquitoes. 2.
openaire   +2 more sources

A dataset and benchmark for malaria life-cycle classification in thin blood smear images

Neural computing & applications (Print), 2021
Malaria microscopy, microscopic examination of stained blood slides to detect parasite Plasmodium, is considered to be a gold standard for detecting life-threatening disease malaria.
Qazi Ammar Arshad   +6 more
semanticscholar   +1 more source

Morphologie, biologie et cycle des Plasmodium parasites de l’homme

Bulletin de l'Académie Nationale de Médecine, 2007
Laveran first discovered that an infectious agent was responsible for malaria by using a simple microscope, without the assistance of specific stains. Our knowledge of the Plasmodium life cycle and cellular biology has progressed with each technological advance, from Romanovsky staining and histology to electron microscopy, immunocytochemistry ...
openaire   +3 more sources

Plasmodium vivax

2013
Plasmodium vivax has unique attributes to support its survival in varying ecologies and climates. These include hypnozoite forms in the liver, an invasion preference for reticulocytes, caveola-vesicle complex structures in the infected erythrocyte membrane and rapidly forming and circulating gametocytes.
John W. Barnwell   +3 more
openaire   +3 more sources

Pyrimidine de novo Synthesis during the Life Cycle of the Intraerythrocytic Stage of Plasmodium falciparum

The Journal of Parasitology, 1984
The 6 enzymes involved in de novo synthesis of pyrimidines were measured in Plasmodium falciparum isolated by saponin lysis from RBC's nonsynchronized and synchronized in vitro cultures. The total activities were found to be dependent on the stage of the P. falciparum cycle.
Annette M. Gero   +2 more
openaire   +3 more sources

Protein phosphorylation during the asexual life cycle of the human malarial parasite Plasmodium falciparum

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1990
Recent evidence has suggested that extensive changes in the phosphorylation profile of red cell membrane proteins are associated with the invasion and development of the malarial parasite. In order to further define the role of parasite protein phosphorylation in these events we have looked at this phosphorylation using: (1) continuous metabolic ...
Graham L. Jones   +1 more
openaire   +3 more sources

An ApiAp2 Transcription Factor with a Dispensable Role in Plasmodium berghei Life Cycle

ACS Infectious Diseases
Malaria parasites have a complex life cycle and undergo replication and population expansion within vertebrate hosts and mosquito vectors. These developmental transitions rely on changes in gene expression and chromatin reorganization that result in the activation and silencing of stage-specific genes. The ApiAp2 family of DNA-binding proteins plays an
null Nirdosh   +2 more
openaire   +2 more sources

OBSERVATIONS ON THE LIFE‐CYCLE OF PLASMODIUM MALARIAE

Australian Journal of Experimental Biology and Medical Science, 1948
M. J. Mackerras, QN Ercole
openaire   +3 more sources

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