Results 81 to 90 of about 68,345 (214)

Predicting the direct and indirect impacts of climate change on malaria in coastal Kenya.

PLoS ONE, 2019
BACKGROUND:The transmission of malaria is highly variable and depends on a range of climatic and anthropogenic factors. This study investigates the combined, i.e.
Phong V V Le, Praveen Kumar, Marilyn O Ruiz, Charles Mbogo, Ephantus J Muturi   +4 more
doaj   +1 more source

Plasmodium falciparum Development from Gametocyte to Oocyst: Insight from Functional Studies

Microorganisms, 2023
Malaria elimination may never succeed without the implementation of transmission-blocking strategies. The transmission of Plasmodium spp. parasites from the human host to the mosquito vector depends on circulating gametocytes in the peripheral blood of ...
Dinkorma T. Ouologuem, Antoine Dara, Aminatou Kone, Amed Ouattara, Abdoulaye A. Djimde   +4 more
doaj   +1 more source

Long‐term impact of exposure to Royal Guard, a pyriproxyfen‐based bed net, on pyrethroid‐resistant malaria vectors from Cameroon using DNA‐based metabolic resistance markers

Pest Management Science, Volume 81, Issue 4, Page 2165-2180, April 2025.
We used recently detected P450 DNA‐based markers of pyrethroid resistance in both Anopheles funestus and Anopheles gambiae to demonstrate that although pyrethroid‐resistant mosquitoes have higher ability to survive and live longer after exposure to Royal Guard, this net significantly affects their lifespan, blood feeding ability and interestingly ...
Emilie S Ngongang‐Yipmo, Magellan Tchouakui, Benjamin D Menze, Riccado F Tiomela, Derrick Fofie, Vanessa B Ngannang‐Fezeu, Jean L Mugenzi, Flobert Njiokou, Charles S Wondji   +8 more
wiley   +1 more source

Detecting signatures of balancing selection to identify targets of anti-parasite immunity.

, 2010
Parasite antigen genes might evolve under frequency-dependent immune selection. The distinctive patterns of polymorphism that result can be detected using population genetic methods that test for signatures of balancing selection, allowing genes encoding
Conway, David J, Weedall, Gareth D
core   +1 more source

Avian malaria co-infections confound infectivity and vector competence assays of Plasmodium homopolare. [PDF]

, 2018
Currently, there are very few studies of avian malaria that investigate relationships among the host-vector-parasite triad concomitantly. In the current study, we experimentally measured the vector competence of several Culex mosquitoes for a newly ...
Barker, Christopher M, Carlson, Jenny S, Cornel, Anthony J, Nelms, Brittany, Reisen, William K, Sehgal, Ravinder NM   +5 more
core   +1 more source

Robust Bioconjugated Antigens Induce Immune Responses Preventing Malaria Infection and its Transmission

Small, EarlyView.
Engineered malaria antigens enable in vivo bioconjugation to submicron biopolymer particles in E. coli. Two antigens are co‐tethered at high density and defined stoichiometry. The resulting thermostable particles elicit strong, durable antibody and T‐cell responses, conferring robust protection and blocking mosquito transmission.
Nivethika Sivakumaran, Yevel Flores‐Garcia, Chanel M. Naar, Shuxiong Chen, Mili Mehta, Fijs W. B. van Leeuwen, Abhai Tripathi, Rajagopal Murugan, Meta Roestenberg, Fidel Zavala, Bernd H. A. Rehm   +10 more
wiley   +1 more source

A Comprehensive Survey of the Plasmodium Life Cycle by Genomic, Transcriptomic, and Proteomic Analyses

Science, 2005
Plasmodium berghei and Plasmodium chabaudi are widely used model malaria species. Comparison of their genomes, integrated with proteomic and microarray data, with the genomes of Plasmodium falciparum and ...
Neil, Hall, Marianna, Karras, J Dale, Raine, Jane M, Carlton, Taco W A, Kooij, Matthew, Berriman, Laurence, Florens, Christoph S, Janssen, Arnab, Pain, Georges K, Christophides, Keith, James, Kim, Rutherford, Barbara, Harris, David, Harris, Carol, Churcher, Michael A, Quail, Doug, Ormond, Jon, Doggett, Holly E, Trueman, Jacqui, Mendoza, Shelby L, Bidwell, Marie-Adele, Rajandream, Daniel J, Carucci, John R, Yates, Fotis C, Kafatos, Chris J, Janse, Bart, Barrell, C Michael R, Turner, Andrew P, Waters, Robert E, Sinden   +29 more
openaire   +2 more sources

Crystal structure of Plasmodium vivax macrophage migration inhibitory factor

Acta Crystallographica Section F, EarlyView.
The production, crystallization and 1.8 Å resolution crystal structure of macrophage migratory inhibitory factor from P. vivax are reported.Plasmodium vivax is a major cause of malaria globally and has recently been transmitted locally in the USA. P. vivax produces homologs of host proteins, including cytokines such as macrophage migration inhibitory ...
Aryana Nair, Matthew Lin, Arav Srivastava, Lijun Liu, Anne Cooper, Kevin Battaile, Elizabeth Harmon, Peter J. Myler, Bart L. Staker, Scott Lovell, Graham Chakafana, Oluwatoyin A. Asojo   +11 more
wiley   +1 more source

Autophagy protein Atg7 is essential for maintaining malaria parasite cellular homeostasis and organelle biogenesis

mBio
Plasmodium parasites have a complex life cycle that transitions between mosquito and mammalian hosts, and undergo continuous cellular remodeling to adapt to various drastic environments.
Akancha Mishra, Suryansh Rajput, Pratik Narain Srivastava, H. Shabeer Ali, Satish Mishra   +4 more
doaj   +1 more source

A putative homologue of CDC20/CDH1 in the malaria parasite is essential for male gamete development.

PLoS Pathogens, 2012
Cell-cycle progression is governed by a series of essential regulatory proteins. Two major regulators are cell-division cycle protein 20 (CDC20) and its homologue, CDC20 homologue 1 (CDH1), which activate the anaphase-promoting complex/cyclosome (APC/C ...
David S Guttery, David J P Ferguson, Benoit Poulin, Zhengyao Xu, Ursula Straschil, Onny Klop, Lev Solyakov, Sara M Sandrini, Declan Brady, Conrad A Nieduszynski, Chris J Janse, Anthony A Holder, Andrew B Tobin, Rita Tewari   +13 more
doaj   +1 more source