Results 121 to 130 of about 151,016 (323)
A randomised trial of an eight-week, once weekly primaquine regimen to prevent relapse of plasmodium vivax in Northwest Frontier Province, Pakistan. [PDF]
, 2008 BACKGROUND: Vivax malaria remains a major cause of morbidity in the subtropics. To undermine the stability of the disease, drugs are required that prevent relapse and provide reservoir reduction. A 14-day course of primaquine (PQ) is effective but cannot
Erasmus, Panna +6 more
core +3 more sources
A Silicon Rhodamine‐fused Glibenclamide to Label and Detect Malaria‐infected Red Blood Cells
ChemBioChem, Volume 26, Issue 7, April 1, 2025.A far‐red fluorescent silicon rhodamine‐conjugated glibenclamide (SiR‐glib) is synthesized. Labeling experiments in cells reveal the endoplasmic reticulum as the primary target of SiR‐glib, and is applicable to detect malaria‐infected red blood cells.
Claudia Bastl +21 more
wiley +1 more source
Nature Communications, 2018 Malaria liver stages represent an ideal therapeutic target with a bottleneck in parasite load and reduced clinical symptoms; however, current in vitro pre-erythrocytic (PE) models for Plasmodium vivax and P.
Alison Roth +26 more
semanticscholar +1 more source
Avian malaria co-infections confound infectivity and vector competence assays of Plasmodium homopolare. [PDF]
, 2018 Currently, there are very few studies of avian malaria that investigate relationships among the host-vector-parasite triad concomitantly. In the current study, we experimentally measured the vector competence of several Culex mosquitoes for a newly ...
Barker, Christopher M +5 more
core +1 more source
Exploring Aspartate Transcarbamoylase: A Promising Broad‐Spectrum Target for Drug Development
ChemBioChem, Volume 26, Issue 7, April 1, 2025.Pyrimidine biosynthesis is a pivotal process shared by both eukaryotes and prokaryotes. This review examines the applications and advantages of a series of inhibitors specifically designed to target aspartate transcarbamylase within the de novo biosynthetic pathway of the malarial parasite.
Siyao Chen +8 more
wiley +1 more source
Immunity against sexual stage Plasmodium falciparum and Plasmodium vivax parasites
Immunological Reviews, 2019 The efficient spread of malaria from infected humans to mosquitoes is a major challenge for malaria elimination initiatives. Gametocytes are the only Plasmodium life stage infectious to mosquitoes.
Roos M. de Jong +6 more
semanticscholar +1 more source
Brazilian Journal of Infectious Diseases, 2010 This report describes the development of hemolysis in eighteen glucose-6-phosphate dehydrogenase deficient patients treated for Plasmodium vivax malaria with chloroquine and primaquine.
Wilson M. Ramos Júnior +5 more
doaj
Malaria Journal, 2019 Background Following the scale-up of intervention efforts, malaria burden has decreased dramatically in Solomon Islands (SI). Submicroscopic and asymptomatic Plasmodium vivax infections are now the major challenge for malaria elimination in this country.
Yi Wan Quah +12 more
doaj +1 more source
Retinal Hemorrhages in Severe Non-cerebral Plasmodium vivax Malaria in an Adult [PDF]
Journal of Clinical and Diagnostic Research, 2015 Malaria is the most important parasitic diseases of humans and one of the leading causes of morbidity and mortality in tropical countries. Earlier Plasmodium vivax was considered as a benign infection, but now it is recognized as a cause of severe ...
Manoj Lakhotia +4 more
doaj +1 more source
Circulating Growth Differentiation Factor 15 (GDF15) in Paediatric Disease: A Systematic Review
Journal of Cachexia, Sarcopenia and Muscle, Volume 16, Issue 2, April 2025.ABSTRACT Background Growth Differentiation Factor 15 (GDF15), a nonspecific inflammatory marker and member of the TGF‐β superfamily, has a well‐established role in both inflammation and metabolic modulation, but lacks a comprehensive paediatric literature review.
David W. Kronenberger +3 more
wiley +1 more source