Results 231 to 240 of about 50,973 (273)

IgG‐Bridging–Seeded Synergistic Aggregation of SARS‐CoV‐2 Spikes Underlies Potent Neutralization by a Low‐Affinity Antibody

Advanced Science, EarlyView.
Low‐affinity antibodies are frequently disregarded in discovery pipelines. This work reports P5‐1C8, a Class 1 SARS‐CoV‐2 antibody with weak trimer binding (KD‐to‐IC50 > 3700‐fold) yet potent neutralization of Omicron JN.1. Structural, biophysical, functional, and coarse‐grained simulations collectively demonstrate that transient inter‐spike IgG ...
Niannian Lv, Peng Chen, Xiaobin Dai, Hu Xu, Ziheng Li, Zelin Shan, Jinqian Li, Fenglin Guo, Yuanfang Chen, Jiayi Li, Yiqian Huang, Guizhi Dong, Yifan Jiang, Liang Chen, Xuanyu Nan, Hanjun Zhao, Kang Zhang, Shilong Fan, Yuanchen Dong, Dongsheng Liu, Xinquan Wang, Deli Huang, Xiaojing Pan, Chunying Chen, Zhihua Liu, Li‐Tang Yan, Qi Zhang, Linqi Zhang, Yuliang Zhao, Yuhe Renee Yang   +29 more
wiley   +1 more source

Long lived surface plasmons on the interface of a metal and a photonic time-crystal. [PDF]

Nanophotonics
Bar-Hillel L, Plotnik Y, Segal O, Segev M.   +3 more
europepmc   +1 more source

A Reactive Antagonist Strategy: Cysteine‐Directed Covalent Molecular Glue in Plant Hormone Receptor Regulation

Advanced Science, EarlyView.
The plant hormone jasmonate is perceived by COI1‐JAZ co‐receptors comprising a single F‐box protein COI1 and multiple JAZ repressors with overlapping functions, complicating genetic analysis. We present a reactive antagonist (RA) strategy that selectively promotes COI1 binding to a cysteine‐engineered JAZ variant while blocking wild‐type JAZs, enabling
Minoru Ueda, Kotaro Matsumoto, Takao Nomura, Yousuke Takaoka, Taichi Okumura, Wataru Kozaki, Hikaru Hoshikawa, Yuho Nishizato, Andrea Chini, Roberto Solano, Katsumi Maenaka   +10 more
wiley   +1 more source

Towards field-resolved visible microscopy of 2D materials. [PDF]

Nanophotonics
Kim D, Mamaikin M, Krausz F, Karpowicz N.   +3 more
europepmc   +1 more source

A Scalable Method for Cavity‐Enhanced Solid‐State Quantum Sensors

Advanced Science, EarlyView.
Photoluminescent color centres in diamond and hexagon boron nitride are powerful nanoscale solid‐state quantum sensors. Methods for integrating them into macroscopic structures that improve their sensitivity are highly sought after. This study demonstrates a low‐cost and scalable method for the fabrication of quantum sensor‐doped thin‐film cavities ...
Daniel J. Tibben, Roy Styles, David A. Broadway, Jean‐Philippe Tetienne, Daniel E. Gómez, Philipp Reineck   +5 more
wiley   +1 more source

Ultrafast momentum-resolved visualization of the interplay between phonon-mediated scattering and plasmons in graphite. [PDF]

Sci Adv
Barantani F, Claude R, Iyikanat F, Madan I, Sapozhnik AA, Puppin M, Weaver B, LaGrange T, de Abajo FJG, Carbone F.   +9 more
europepmc   +1 more source

Machine Learning‐Enhanced Analysis of Exosomal Surface Sialic Acid Using Surface‐Enhanced Raman Spectroscopy for Ovarian Cancer Diagnosis and Therapeutic Monitoring

Advanced Science, EarlyView.
Machine learning‐assisted surface‐enhanced Raman spectroscopy analysis of exosomal sialic acid for ovarian cancer diagnosis, as well as independent monitoring of exosomal sialic acid expression levels across different treatment periods, reveals a potential correlation with treatment response.
Lili Cong, Jiaqi Wang, Sijun Huang, Xiaxia Man, Yi Guo, Shuping Xu, Songling Zhang   +6 more
wiley   +1 more source

Tunable Strong Plasmon-Exciton Coupling in a Low-Loss Nanocuboid Dimer with Monolayer WS₂. [PDF]

Nanomaterials (Basel)
Wu F, Chen Z.
europepmc   +1 more source

Potent and Selective IGF‐IIR‐Recruiting Bifunctional Molecules for Targeted Lysosomal Degradation of Extracellular and Membrane Proteins

Advanced Science, EarlyView.
Lysosome‐targeting chimeras (LYTACs) enable degradation of extracellular and membrane proteins via lysosomal trafficking. We report a novel IGF‐II mutant (Del1–7, Y27L) that selectively engages IGF‐IIR while avoiding IGF‐IR and IR‐A. mutIGF‐II–based LYTACs enhance target internalization and degradation and support a genetically encodable, all‐protein ...
Yuan Zhao, Yaxian Liao, Pengyun Li, Regina Stasser de Gonzalez, Xuankun Chen, Nicholas S. Nieto, Florence M. Brunel, Nick Cox, Joseph Stock, Matthew McHenry, Guangsen Fu, Penghsuan Huang, Wenxin Wu, Deqin Cai, Lingjun Li, Alexander N. Zaykov, Weiping Tang   +16 more
wiley   +1 more source

Probing amplified Josephson plasmons in YBa₂Cu₃O_6+x by multidimensional spectroscopy. [PDF]

NPJ Quantum Mater
Taherian N, Först M, Liu A, Fechner M, Pavicevic D, von Hoegen A, Rowe E, Liu Y, Nakata S, Keimer B, Demler E, Michael MH, Cavalleri A.   +12 more
europepmc   +1 more source