Results 91 to 100 of about 710,527 (288)

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Ecotoxicity of plastic additives to marine organisms

Anais da Academia Brasileira de Ciências
Marine pollution by plastics is a major environmental issue that is expected to increase worldwide. Thousands of chemical substances can be used as plastic additives in industrial processes for various purposes, turning plastics into chemical carriers of
DENIS M.S. ABESSA, GABRIEL M. IZAR, GIAM LUCA ALTAFIM, LETÍCIA A. FRANÇA   +3 more
doaj   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Automated solid phase extraction combined with gas chromatography-mass spectrometry methods for plastic and tire additives in surface waters: development, validation and greenness assessment

Green Analytical Chemistry
Automated solid phase extraction (SPE) combined with gas chromatography-mass spectrometry (GC–MS) methods were proposed for determination of plastic and tire additives in surface water. The plastic additives studied were phthalates (PAEs) and bisphenols (
N. Carro, N. Díaz, J. Cobas, I. García, A. Mouteira, M. Ignacio   +5 more
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Migration of chemical compounds from food packaging: regulatory aspects and assessment of potential risks

Journal of Social Sciences
Plastics have become prevalent in food packaging, although the transfer of additives with potential for migration into food is a significant public health concern.
STURZA, Rodica, GHENDOV-MOȘANU, Aliona, DRAGANCEA, Veronica, LAZACOVICI, Dmitri   +3 more
doaj   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Towards an equitable approach to marine plastic pollution

, 2022
Current forms of marine plastic pollution and waste governance can, in some cases, exacerbate their inequitable burdens, and these burdens are likely to increase as plastics production continues to grow and be mismanaged.
Yoshi O, Vandenberg J, Farrelly T
core  

Additives in Plastics Applications

CHIMIA, 2002
The use of light stabilizers, e.g. UV-absorbers (UVA) and Hindered Amine Light Stabilizers (HALS) in thermoplastic polymers is highlighted. Examples are shown of what can be achieved in natural outdoor weathering as well as in accelerated weathering devices with UVA, HALS, UVA/HALS combinations, HALS/HALS combinations, and the latest NOR-HALS
Roberto V. Todesco, Nadi Ergenc
openaire   +3 more sources

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source