Results 101 to 110 of about 68,956 (308)

Fibrates Inhibit PLTP‐induced M2 Macrophage Infiltration and Increase the Sensitivity of Hepatocellular Carcinoma to ICIs

Advanced Science, EarlyView.
Phospholipid transfer protein(PLTP) plays a critical role in forming a complex with kinase A (AURKA) and P65. This interaction facilitates phosphorylation of P65 at Ser536, leading to the activation of the NF‐κB signaling pathway. Ultimately, this leads to the upregulation of downstream cytokines, including IL‐6, IL‐8, and CSF‐1, which promotes M2 ...
Xinyue Liang, Yaning Li, Jianxun Cai, Lisi Luo, Pengfei Yang, Yutong Chen, Jiancong Zhou, Yan Zeng, Jiaping Yu, Weiyu Zhang, Wenzheng Pang, Yufang Li, Chunhua Wen, Jian Li, Linjuan Zeng   +14 more
wiley   +1 more source

Plastic Shrinkage Properties of Natural Fiber Reinforced Shotcrete

, 2019
Recently, natural hemp fibers have been developed for use in wet or dry mix shotcrete instead of conventional synthetic fibers made from petroleum. Synthetic fibers, which is mainly in polypropylene, has been used for controlling an initial shrinkage ...
Yun, Kyong-Ku, HAN, Seung-Yeon, BAEK, Yoon-Sik, KIM, Yong-Gon   +3 more
core  

In Situ X‐Ray Tomography and Acoustic Emission Monitoring of Damage Evolution in C/C‐SiC Composites Fabricated by Liquid Silicon Infiltration

Advanced Science, EarlyView.
This study investigates how the internal structure of fiber‐reinforced ceramic composites affects their resistance to damage. By combining 3D X‐ray imaging with acoustic emission monitoring during mechanical testing, it reveals how silicon distribution influences crack formation.
Yang Chen, Renato S. M. Almeida, Stefan Flauder, Guillaume Couégnat, Kamen Tushtev, Jürgen Horvath, Peter Wriggers, Kurosch Rezwan   +7 more
wiley   +1 more source

Cigarette filter material and polypropylene fibres in concrete to control drying shrinkage

, 2012
Due to a reduction in demand for cigarette filter material (North East UK), significant quantities have arisen that have little commercial value. The filter manufacturers have been looking for another outlet for their product and polypropylene fibre ...
Richardson, Alan
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Dual‐Responsive Dynamic Covalent Bond‐Based Assembly of Lipid‐Nanozyme Systems via Multi‐Target Synergy and Efficient Target Enrichment for Ischemic Stroke Therapy

Advanced Science, EarlyView.
This system adopts a biomimetic phospholipid structure, covalently binding iNOS inhibitors, neuroprotective agent PCA and vitamin E derivatives through pH/ROS dual‐responsive bonds, and assembles them with Prussian blue nanozyme to form PBB@AHA. It can efficiently penetrate the blood‐brain barrier and simultaneously release multiple active components ...
Mengcheng Guo, Qingran Guan, Guanyu Qiao, Lixue Zhang, Man Liu, Zhen Li, Qingbiao Yang, Meili Shen, Linlin Liu, Yapeng Li   +9 more
wiley   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

A Study on Plastic Shrinkage Coefficient of Crack Opening/Closing Model at a Crack Extension

Journal of the Society of Naval Architects of Japan, 2000
In the previous paper, we developed a simulation model of fatigue crack opening and closing phenomena for predicting RPG load under an arbitrary stress distribution field. By using the simulation model, effects of stress ratio and residual stress distribution on fatigue crack propagation rate are quantitatively assessed.
Niwa, Toshio, Toyosada, Masahiro
openaire   +2 more sources

Wavy‐Interlocked Stretchable Triboelectric Nanogenerators Enhanced by Liquid Metal Microflowers for Self‐Powered Wearable Motion Monitoring

Advanced Science, EarlyView.
Schematic showing a stretchable triboelectric nanogenerator based on interlocked wavy architectures that uses EGaIn microflower‐embedded PVDF‐TrFE and Nylon‐6 nanofiber membranes. The multi‐petaled, electron‐rich EGaIn microflowers enhance interfacial polarization and capacitance, while the interlocked wavy architecture enlarges the effective contact ...
Qianqian Xu, Huimin Li, Hanmin Zeng, Yahui Meng, Yimeng He, Xinke Hu, Senfeng Zhao, Jianxun Zhang, Peiqiong Zhou, Kechao Zhou, Dou Zhang, Chris Bowen, Yan Zhang   +12 more
wiley   +1 more source

Basic Formability Research and Experimental Test of Glass Fiber Reinforced Aluminium Laminates

Journal of Aeronautical Materials, 2017
The basic formability of Glare 2A, Glare 2B and Glare 3 laminates was investigated by unidirectional tensile and three-point bending tests to explore the formability characteristics of Glare.
TIAN Jingming, LI Huaguan, LIU Cheng, TAO Gang, ZHANG Liqing, ZHENG Xingwei, LIU Hongbing, TAO Jie   +7 more
doaj   +1 more source

CRACKS IN REINFORCED CONCRETE BEAM

, 2022
Cracks in concrete cannot be prevented but the size of the cracks can be controlled. Cracks that occur in concrete are strongly influenced by the nature and characteristics of the concrete constituent materials, especially cement and water.
Layang, Samuel
core