Results 41 to 50 of about 35,895 (307)

Plastic collapse analysis in multiaxially loaded defective pipe specimens at different temperatures

open access: yesJournal of Pipeline Science and Engineering, 2023
A comprehensive numerical investigation is carried out using a newly developed constitutive model to describe failure at low temperatures in multiaxially loaded cracked pipes made of 316L stainless steel.
Y. Li, C. Sakonder, M. Paredes
doaj   +1 more source

Loading Surface in the Course of Mechanical- Thermal Treatment and Steady-State Creep of Metals [PDF]

open access: yes, 2013
: Kinetics of the loading surface of a material gives precious information on the level of the hardening of the material. This paper is concerned with the evolution of the loading surface during successive actions, such as: (i) plastic deformation, (ii)
Ruszinkó, Endre
core  

Plasticity-Induced Anisotropy in Amorphous Solids: the Bauschinger Effect

open access: yes, 2010
Amorphous solids that underwent a strain in one direction such that they responded in a plastic manner `remember' that direction also when relaxed back to a state with zero mean stress.
Karmakar, Smarajit   +2 more
core   +1 more source

The effect of material cyclic deformation properties on residual stress generation by laser shock processing [PDF]

open access: yes, 2019
Laser shock processing (LSP) is a mechanical surface treatment to induce a compressive residual stress state into the near surface region of a metallic component.
Angulo, I.   +6 more
core   +1 more source

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

open access: yesMolecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy   +9 more
wiley   +1 more source

Influence of Morphology of Intermetallic Particles on the Microstructure and Properties Evolution in Severely Deformed Al-Fe Alloys

open access: yesMetals, 2021
This study focuses on the difference in microstructural features and physical properties of Al-2Fe and Al-4Fe alloys subjected to large plastic straining.
Andrey Medvedev   +4 more
doaj   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Anisotropic behaviour of compacted clayey silt subjected to hydromechanical paths

open access: yesE3S Web of Conferences, 2016
Compaction induces anisotropy on soil deformational response due to preferential straining associated with the fabrication process. An experimental insight into the stress-strain response of Barcelona clayey silt is provided here.
Buenfil Carlos   +3 more
doaj   +1 more source

INDENTATION SIZE EFFECT IN HIGH PRESSURE TORSION PROCESSED HIGH ENTROPY ALLOY

open access: yesActa Polytechnica CTU Proceedings, 2020
High entropy alloy HfNbTaTiZr in as cast conditions and after high pressure torsion straining was characterized by nanoindentation. The length-scale dependent material response (indentation size effect) was characterized by indentation at various ...
Petr Haušild   +4 more
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

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