Results 21 to 30 of about 255,955 (266)

Metastatic angiosarcoma of the scalp presented as posttraumatic subgaleal hematoma: The many faces of a diagnostic challenge

Radiology Case Reports, 2021
Angiosarcomas represent highly-aggressive malignant lesions of the endothelial cells of blood vessels, affecting mostly the elderly population, and usually located in the scalp or face.
Loai Aker, MD, Mahir Abdulla Petkar, MBBS, MD, FRCRPath, Sohail Jamiluddin Quazi, MCh plastic surgery, Renan Ibrahem Adam, MD, FRCR   +3 more
doaj   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Consensus of Chinese Experts on Neck Injection Aesthetics (2024 Edition)

Xiehe Yixue Zazhi
Neck injection aesthetic, a commonly performed clinical procedure, is still lacking in comprehensive guidelines or consensus. This expert consensus is co-authored by experts from the Injection Aesthetics of the National Quality Control Center of Plastic ...
Professional Panel on Injection Aesthetics, National Quality Control Center for Plastic and Aesthetic Surgery
doaj   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Luminescence and Preventive Effect of Two New Cd(II) Compounds on Scar Formation after Cosmetic Surgery

Journal of Chemistry, 2022
Two coordination polymers involving Cd(II), i.e., [Cd2(IDPA)2(bpe) (H2O)2]n·2n(H2O) (1) (H2IDPA is 5-(1-oxoisoindolin-2-yl)isophthalic acid, bpe is 1,2-bis(4-pyridyl)ethane, 4-bpmh is N, N-bis-pyridin-4-ylmethylene-hydrazine), and [Cd(IDPA)(4-bpmh)0.5 ...
Zhi-Ming Yuan, Ze-Xu Lin, Shui-Lian Chen, Xin Lin   +3 more
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Plastic Surgery Fellowship at Nippon Medical School Hospital: An Integrative Approach to Modern Plastic Surgery Education

Plastic and Reconstructive Surgery, Global Open, 2021
Summary:. Plastic surgery requires extensive wide-ranging surgical knowledge, special technical dexterity, and personal skills in order to achieve improved quality of life and satisfying outcomes for patients.
Mohamed Abdelhakim, MD, Carolina Soto Diez, MD, Chenyu Huang, MD, PhD, Ioannis Goutos, FRCSEd, Dennis P. Orgill, MD, PhD, Rei Ogawa, MD, PhD, FACS   +5 more
doaj   +1 more source

Bariatric plastic surgery [PDF]

Aesthetic Surgery Journal, 2003
As aesthetic surgeons, we have an interest not only in the appearance of our patients but also in their general health. Obesity undeniably has a great impact on both. As radical but effective procedures to treat obesity become more common, as is happening now, our surgical expertise in treating the after-effects of massive weight loss will be in ...
openaire   +2 more sources