Results 71 to 80 of about 139,021 (263)

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Microstructural Characterization Of Quenched And Plastically Deformed Two-Phase α+β Titanium Alloys

Archives of Metallurgy and Materials, 2015
Development of microstructure in two-phase α+β titanium alloys is realized by thermomechanical processing – sequence of heat treatment and plastic working operations.
Motyka M., Sieniawski J., Ziaja W., Mrówka-Nowotnik G.   +3 more
doaj   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

Development of Transmission Error Dynamic Testing Machine for Plastic Gear

Jixie chuandong, 2019
Based on the principle of single flank measurement, a dynamic testing machine for plastic gear transmission error is developed and can simulate the actual working condition of the plastic gear and realize the dynamic measurement of transmission error ...
Zhaoyao Shi, Xinli Ren, Bo Yu, Haizhou Li, Lintao Zhang, Yong Ye, Ping Li   +6 more
doaj  

Study on the evolution laws of overlying strata stress and mining-induced fracture zones under coordinated extraction in multi-working face areas

Frontiers in Earth Science
With the continuous increase in coal mining depth and intensity, the stress distribution in surrounding rock during multi-working face coordinated mining has become increasingly complex, significantly affecting the safe and efficient extraction of coal ...
Xinkuan Bai, Qiang Yuan, Qian Jiang, Qian Jiang, Jun Song, Zhu Chen, Xiaoliang Liu   +6 more
doaj   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Construction of Medical Quality Control Indicators System for Chinese Plastic and Aesthetic Major

Xiehe Yixue Zazhi
ObjectiveTo construct a quality control indicators system for Chinese plastic and aesthetic major and lay foundation for medical quality control.MethodsNational Quality Control Center of Plastic and Aesthetic Major established a working group in February
ZHANG Mingzi, SI Loubin, HUANG Jiuzuo, YU Nanze, ZHENG Jiaojie, CHEN Jie, WANG Xiaojun, LONG Xiao, XIONG Wei   +8 more
doaj   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source