Results 91 to 100 of about 1,418,382 (391)

A Plastic Clock [PDF]

open access: yesNeuron, 2013
Although circadian clocks normally run with a 24 hr period, Brancaccio et al. (2013) report in this issue of Neuron that transiently activating G protein signaling can lengthen period even after the stimulus is removed, revealing an unexpected plasticity in the central brain clock.
Ben Collins, Justin Blau
openaire   +3 more sources

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

open access: yesMolecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu   +11 more
wiley   +1 more source

Long-term and persistent vocal plasticity in adult bats. [PDF]

open access: yes, 2019
Bats exhibit a diverse and complex vocabulary of social communication calls some of which are believed to be learned during development. This ability to produce learned, species-specific vocalizations - a rare trait in the animal kingdom - requires a ...
Desai, Janki   +3 more
core   +1 more source

Non-local fractional model of rate independent plasticity [PDF]

open access: yes, 2013
In the paper the generalisation of classical rate independent plasticity using fractional calculus is presented. This new formulation is non-local due to properties of applied fractional differential operator during definition of kinematics.
Sumelka, Wojciech
core   +1 more source

A simplified microwave-based motion detector for home cage activity monitoring in mice

open access: yesJournal of Biological Engineering, 2017
Background Locomotor activity of rodents is an important readout to assess well-being and physical health, and is pivotal for behavioral phenotyping.
Andreas Genewsky   +4 more
doaj   +1 more source

Beyond buying time: the role of plasticity in phenotypic adaptation to rapid environmental change

open access: yesPhilosophical Transactions of the Royal Society of London. Biological Sciences, 2019
How populations and species respond to modified environmental conditions is critical to their persistence both now and into the future, particularly given the increasing pace of environmental change.
R. Fox   +4 more
semanticscholar   +1 more source

Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry

open access: yesMolecular Oncology, EarlyView.
Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson   +11 more
wiley   +1 more source

Fluctuating population dynamics promotes the evolution of phenotypic plasticity [PDF]

open access: yes, 2007
An increasing number of studies are showing evidence in support of sympatric speciation. One basic question remains, however. When a population has undergone a branching in its phenotype, is this due to an evolutionary branching in the underlying ...
Mario Pineda-Krch   +2 more
core   +2 more sources

Functional partitioning of sentence processing and emotional prosody in the right perisylvian cortex after perinatal stroke

open access: yesScientific Reports
In healthy adults different language abilities—sentence processing versus emotional prosody—are supported by the left (LH) versus the right hemisphere (RH), respectively.
Kelly C. Martin   +5 more
doaj   +1 more source

NCAM2 Fibronectin type-III domains form a rigid structure that binds and activates the Fibroblast Growth Factor Receptor

open access: yesScientific Reports, 2018
NCAM1 and NCAM2 have ectodomains consisting of 5 Ig domains followed by 2 membrane-proximal FnIII domains. In this study we investigate and compare the structures and functions of these FnIII domains. The NCAM1 and -2 FnIII2 domains both contain a Walker
Kim Krighaar Rasmussen   +13 more
doaj   +1 more source

Home - About - Disclaimer - Privacy