Results 111 to 120 of about 1,298,913 (269)

A new stochastic STDP Rule in a neural Network Model

, 2017
Thought to be responsible for memory, synaptic plasticity has been widely studied in the past few decades. One example of plasticity models is the popular Spike Timing Dependent Plasticity (STDP).
Helson, Pascal
core  

Sleep and plasticity [PDF]

Pflügers Archiv - European Journal of Physiology, 2011
While there is ample agreement that the cognitive role of sleep is explained by sleep-dependent synaptic changes, consensus is yet to be established as to the nature of these changes. Some researchers believe that sleep promotes global synaptic downscaling, leading to a non-Hebbian reset of synaptic weights that is putatively necessary for the ...
openaire   +3 more sources

Soman induces endoplasmic reticulum stress and apoptosis of cerebral organoids via the GRP78‐ATF6‐CHOP signaling pathway

FEBS Open Bio, EarlyView.
Cerebral organoids were employed as a novel model to explore the neurotoxicity of soman. Soman inhibited acetylcholinesterase activity, increased cell apoptosis and upregulated endoplasmic reticulum (ER) stress markers glucose‐regulated protein 78 (GRP78), activating transcription factor 6 (ATF6) and C/EBP homologous protein (CHOP).
Yue Wei, Zhanbiao Liu, Jingjing Shi, Qian Jin, Wenqian Chen, Xuejun Chen, Liqin Li, Hui Chen   +7 more
wiley   +1 more source

Retracted: Three Mediating Pathways of Anxiety and Security in the Relationship between Coping Style and Disordered Eating Behaviors among Chinese Female College Students

Neural Plasticity, 2023
Neural Plasticity
doaj   +1 more source

Processing of Plastics [PDF]

Environmental Health Perspectives, 1975
An overview is given of the processing of plastic materials from the handling of polymers in the pellet and powder form to manufacturing of a plastic fabricated product. Various types of equipment used and melt processing ranges of various polymer formulations to make the myriad of plastic products that are commercially available are discussed.
openaire   +4 more sources

Neurotoxic amyloid β‐peptide and tau produce cytokine‐like effects on PMCA in glioblastoma cell lines, enhancing its activity and isoforms expression

FEBS Open Bio, EarlyView.
Two biomarkers of Alzheimer's disease, amyloid β‐peptide (Aβ) and tau, induce the transformation of U‐251 and other glioblastoma cell lines into neurotoxic A1‐like reactive astrocytes. This transformation is produced by cytokines and is followed by upregulation of PMCA activity and isoform expression, and is closely associated with inflammation, as ...
María Berrocal, Alberto Alvarez‐Barrientos, Ana M. Mata   +2 more
wiley   +1 more source

Long-term and persistent vocal plasticity in adult bats. [PDF]

, 2019
Bats exhibit a diverse and complex vocabulary of social communication calls some of which are believed to be learned during development. This ability to produce learned, species-specific vocalizations - a rare trait in the animal kingdom - requires a ...
Desai, Janki, Genzel, Daria, Paras, Elana, Yartsev, Michael   +3 more
core   +1 more source

Akkermansia muciniphila-induced trained immune phenotype increases bacterial intracellular survival and attenuates inflammation

Communications Biology
The initial exposure to pathogens and commensals confers innate immune cells the capacity to respond distinctively upon a second stimulus. This training capacity might play key functions in developing an adequate innate immune response to the continuous ...
Ainize Peña-Cearra, Ainhoa Palacios, Aize Pellon, Janire Castelo, Samuel Tanner Pasco, Iratxe Seoane, Diego Barriales, Jose Ezequiel Martin, Miguel Ángel Pascual-Itoiz, Monika Gonzalez-Lopez, Itziar Martín-Ruiz, Nuria Macías-Cámara, Naiara Gutiez, Sarai Araujo-Aris, Ana Mª Aransay, Héctor Rodríguez, Juan Anguita, Leticia Abecia   +17 more
doaj   +1 more source

PKCδ is an activator of neuronal mitochondrial metabolism that mediates the spacing effect on memory consolidation

eLife
Relevance-based selectivity and high energy cost are two distinct features of long-term memory (LTM) formation that warrant its default inhibition. Spaced repetition of learning is a highly conserved cognitive mechanism that can lift this inhibition ...
Typhaine Comyn, Thomas Preat, Alice Pavlowsky, Pierre-Yves Plaçais   +3 more
doaj   +1 more source

PaperBot: open-source web-based search and metadata organization of scientific literature

BMC Bioinformatics, 2019
Background The biomedical literature is expanding at ever-increasing rates, and it has become extremely challenging for researchers to keep abreast of new data and discoveries even in their own domains of expertise. We introduce PaperBot, a configurable,
Patricia Maraver, Rubén Armañanzas, Todd A. Gillette, Giorgio A. Ascoli   +3 more
doaj   +1 more source