Results 131 to 140 of about 1,418,382 (391)
Identifying prognostic targets in metastatic prostate cancer beyond AR
FEBS Open Bio, EarlyView.Genome‐wide functional screens combined with a large gene expression database and clinical outcomes can identify new therapeutic vulnerabilities in prostate cancer. Eight potentially druggable targets demonstrated strong dependency in cell lines, were associated with worse prognosis clinically, and showed evidence of protein expression in prostate ...
Emily Feng +13 more
wiley +1 more source
Molecular mechanisms that stabilize short term synaptic plasticity during presynaptic homeostatic plasticity. [PDF]
, 2018 Presynaptic homeostatic plasticity (PHP) compensates for impaired postsynaptic neurotransmitter receptor function through a rapid, persistent adjustment of neurotransmitter release, an effect that can exceed 200%.
Davis, Graeme W +2 more
core +1 more source
Communications BiologyThe initial exposure to pathogens and commensals confers innate immune cells the capacity to respond distinctively upon a second stimulus. This training capacity might play key functions in developing an adequate innate immune response to the continuous ...
Ainize Peña-Cearra +17 more
doaj +1 more source
The Plasticity of Mimesis [PDF]
MLN, 2017 This article inscribes Catherine Malabou's recent philosophical account of brain plasticity in a genealogy that goes, from Lacoue-Labarthe, back to its mimetic origins in Plato's Republic. Este artículo inscribe el reciente relato filosófico de Catherine Malabou sobre la plasticidad cerebral en una genealogía que se remonta, desde Lacoue-Labarthe, a ...
openaire +3 more sources
Current trends in single‐cell RNA sequencing applications in diabetes mellitus
FEBS Open Bio, EarlyView.Single‐cell RNA sequencing is a powerful approach to decipher the cellular and molecular landscape at a single‐cell resolution. The rapid development of this technology has led to a wide range of applications, including the detection of cellular and molecular mechanisms and the identification and introduction of novel potential diagnostic and ...
Seyed Sajjad Zadian +6 more
wiley +1 more source
Nature Communications, 2016 During STDP, the magnitude of postsynaptic Ca2+transients is hypothesized to determine the strength of synaptic plasticity. Here, the authors find that STDP in mature hippocampal synapses does not obey this rule but instead relies on the coordinated ...
Cezar M. Tigaret +4 more
doaj +1 more source
PaperBot: open-source web-based search and metadata organization of scientific literature
BMC Bioinformatics, 2019 Background The biomedical literature is expanding at ever-increasing rates, and it has become extremely challenging for researchers to keep abreast of new data and discoveries even in their own domains of expertise. We introduce PaperBot, a configurable,
Patricia Maraver +3 more
doaj +1 more source
Earthing effects on mitochondrial function: ATP production and ROS generation
FEBS Open Bio, EarlyView.In contrast to sham and naive controls, grounded mitochondria not only exhibit significantly enhanced energy production but also demonstrate a remarkable reduction in membrane potential and oxidative stress. This suggests a profound improvement in mitochondrial health, presenting a promising avenue for therapeutic interventions.
Cecilia Giulivi, Richard Kotz
wiley +1 more source
Crystal plasticity model calibration for 316l stainless steel single crystals during deformation [PDF]
, 2013 Type 316L austenitic stainless steel is an important structural material used for the in-core components and pressure boundaries of light water reactors.
Bogataj, Matej +2 more
core