Results 101 to 110 of about 3,886,063 (302)
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
The Ellipsoid Factor for quantification of rods, plates and intermediate forms in 3D geometries
Frontiers in Endocrinology, 2015 The Ellipsoid Factor (EF) is a method for the local determination of the rod- or plate-like nature of porous or spongy continua. EF at a point within a 3D structure is defined as the difference in axis ratios of the greatest ellipsoid which fits inside ...
Michael eDoube
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Bilancio Sociale 2024 - Opera Cooperativa
European Journal of Volunteering and Community-Based ProjectsL’approvazione del Bilancio Sociale 2024 assume per Opera un significato speciale: coincide, infatti, con il decimo anno di attività della cooperativa, fondata nel 2015.
Mauro Platè
doaj
Dynamic stability and exciting mechanism of a plate supported by air pressure
Nihon Kikai Gakkai ronbunshu, 2016 This paper presents experiments and an analysis on the self-excited vibration of a plate supported by air pressure. The instability conditions are examined using a theoretical analysis considering the effect air compressibility in a chamber.
Masakazu TAKEDA, Masahiro WATANABE
doaj +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Social health insurance: The major driver of unsustainable fiscal policy? [PDF]
During the next decades the populations of most developed countries will grow older as a result of the low level of birth rates since the 1970s and/or the continuously increasing life expectancy.
Hagist, Christian +3 more
core
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Flow Visualisation Studies On Wall Mounted Pitot Type Intake With Splitter Plate [PDF]
, 1991 Flow Visualisation Studies Employing Schlieren/Shadowgraph Technique And -Simple Oil Flow Technique Were Carried Out On A Simple Pitot Type Of 1-Btake With Splitter Plate Mounted On Base Plate In The NAL 0 .3m Tunnel .
Narasimhaswamy, KN, Ramaswamy, MA
core
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source