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Drug Testing and Analysis, EarlyView.Scenarios of drug exposure and administration as well as detection assays for drugs and methods of sports doping published between 2023 and 2024 are critically reviewed and evaluated in context with the Prohibited List 2024 as established by the World Anti‐Doping Agency.
Mario Thevis +2 more
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Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues
ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang +7 more
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Attenuation of experimental proliferative vitreoretinopathy by inhibiting the platelet-derived growth factor receptor [PDF]
イクノ, ヤスシ, 生野, 恭司
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Journal of Oral Pathology & Medicine, 2008
Background: Platelet‐derived growth factor (PDGF)‐AA isoform and its receptor, PDGF‐α receptor (PDGFRA) regulate tooth development and growth. We investigated the expression of both proteins in ameloblastomas, to contribute the understanding of the potential role of the PDGF/PDGFR system in this odontogenic neoplasm.Method: Twenty‐nine specimens of ...
Nikolaus Wick +3 more
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Background: Platelet‐derived growth factor (PDGF)‐AA isoform and its receptor, PDGF‐α receptor (PDGFRA) regulate tooth development and growth. We investigated the expression of both proteins in ameloblastomas, to contribute the understanding of the potential role of the PDGF/PDGFR system in this odontogenic neoplasm.Method: Twenty‐nine specimens of ...
Nikolaus Wick +3 more
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Signal Transduction by the Platelet-Derived Growth Factor Receptor [PDF]
Science, 1989 When platelet-derived growth factor (PDGF) binds to its receptor on a quiescent fibroblast or smooth muscle cell, it stimulates a remarkably diverse group of biochemical responses, including changes in ion fluxes, activation of several kinases, alterations in cell shape, increased transcription of a number of genes, and stimulation of enzymes that ...
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Commentary Signal transduction by the receptors for platelet-derived growth factor
Journal of Cell Science, 1990ABSTRACT Platelet-derived growth factor CPDGF) is a connective tissue cell mitogen that originally was purified from human platelets, but recently has been found to be produced by many different cell types (reviewed by Ross et al. 1986; Heldin and Westermark, 1989). The in vivo function of PDGF remains speculative, but the fact that PDGF
Westermark B, C H Heldin
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Journal of Dermatological Science, 1998
Scleroderma is a fibrotic disease occurring in a localized or systemic form. The pathogenesis of scleroderma remains poorly understood. Recent studies revealed that various cytokines and growth factors were involved in the development of scleroderma fibrosis.
Zhang Jian-zhong +3 more
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Scleroderma is a fibrotic disease occurring in a localized or systemic form. The pathogenesis of scleroderma remains poorly understood. Recent studies revealed that various cytokines and growth factors were involved in the development of scleroderma fibrosis.
Zhang Jian-zhong +3 more
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Platelet derived growth factor and its receptor in intracerebral hemorrhage
Journal of Zhejiang University (Medical Sciences), 2022Intracerebral hemorrhage (ICH) is a common and highly disabling or fatal neurological disorder in adults. Recent studies have suggested that the platelet derived growth factor (PDGF) signaling pathway plays an important role in the development of ICH. PDGF is involved in vascular remodeling and can be used as a biomarker of cerebral amyloid angiopathy ...
Baojie, Mao, Ming, Wang, Shu, Wan
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The platelet-derived growth factor receptor as a therapeutic target
Current Oncology Reports, 2007Several small molecule tyrosine kinase inhibitors that block the epidermal growth factor receptor and vascular endothelial growth factor receptor function are among the many recently developed targeted anticancer therapeutic agents. Increasing evidence indicates that inhibition of other tumor stromal targets could provide additional and possibly ...
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[8] methods for studying the platelet-derived growth factor receptor
1985Publisher Summary This chapter discusses the factors that affect [ 125 I] platelet-derived growth factory (PDGF) binding, or the evaluation of binding, on the evidence that the observed binding is to a functional receptor and on the development of a radioreceptor assay for PDGF. It is a basic 30,000-dalton protein.
Daniel F. Bowen-Pope, Russell Ross
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