Results 171 to 180 of about 46,851 (215)

Yerba Mate (Ilex paraguariensis St. Hill.) Tea May Have Cardiometabolic Beneficial Effects in Healthy and At‐Risk Subjects: A Randomized, Controlled, Blind, Crossover Trial in Nonhabitual Consumers

Molecular Nutrition &Food Research, EarlyView.
Yerba mate intake shows cardiometabolic beneficial effects decreasing blood pressure, blood lipids, inflammatory biomarkers and body fat in healthy and hypercholesterolemic non‐habitual consumers. ABSTRACT Yerba mate has been reported to have antihypertensive, hypocholesterolemic, antidiabetic, or antiobesity properties.
Laura Bravo, Sara Martínez‐López, Jose Luis Sierra‐Cinos, Raquel Mateos, Beatriz Sarriá   +4 more
wiley   +1 more source

Proteomic Insight Into Alzheimer's Disease Pathogenesis Pathways

PROTEOMICS, EarlyView.
ABSTRACT Alzheimer's disease (AD) is a leading cause of dementia, but the pathogenesis mechanism is still elusive. Advances in proteomics have uncovered key molecular mechanisms underlying AD, revealing a complex network of dysregulated pathways, including amyloid metabolism, tau pathology, apolipoprotein E (APOE), protein degradation ...
Taekyung Ryu, Kyungdo Kim, Nicholas Asiimwe, Chan Hyun Na   +3 more
wiley   +1 more source

Hetrombopag: A promising thrombopoietin receptor agonist for the treatment of primary and secondary immune thrombocytopenia

Rheumatology &Autoimmunity, EarlyView.
This review seeks to provide a thorough synthesis of the existing literature on the role of thrombopoietin receptor agonists in the treatment of primary and secondary immune thrombocytopenia, with particular emphasis on the compound Hetrombopag. Abstract Immune thrombocytopenia (ITP) is a rare autoimmune disorder characterized by a platelet count below
Jiaqi Hu, Zhida Fu, Xia Xu, Zhengyi Jin, Xinyu Qian, Weiyu Tao, Taiyan Ma, Dongbao Zhao, Jie Gao   +8 more
wiley   +1 more source

Nature Inspired Delivery Vehicles for CRISPR‐Based Genome Editing

Small, EarlyView.
The review highlights nature‐inspired nanocarriers for CRISPR delivery, emphasizing viral vectors, extracellular vesicles, liposomes, and lipid nanoparticles. It discusses their roles in improving specificity, minimizing immunogenicity, and overcoming barriers in genome editing. Recent advancements, challenges, and therapeutic applications are explored,
Elizabeth Maria Clarissa, Mamata Karmacharya, Hyunmin Choi, Sumit Kumar, Yoon‐Kyoung Cho   +4 more
wiley   +1 more source

Near‐Infrared Fluorescent Single‐Walled Carbon Nanotubes for Biosensing

Small, EarlyView.
Near‐infrared fluorescent single‐walled carbon nanotubes (SWCNTs) stand out as versatile biosensors due to their spectral overlap with the biological transparency window, surface‐sensitive fluorescence emission, and chemical modularity. This review offers a concise guide to understanding the photophysics of SWCNTs, various functionalization strategies,
Srestha Basu, Gili Bisker
wiley   +1 more source

Exploring 2D Graphene‐Based Nanomaterials for Biomedical Applications: A Theoretical Modeling Perspective

Small Science, EarlyView.
Two‐dimensional graphene‐based nanomaterials are of significant interest in biomedical applications due to their unique physicochemical properties. Computational modeling provides useful insights into their structure and interactions with biological systems, aiding the nanoparticle design.
Alexa Kamboukos, Nevena Todorova, Irene Yarovsky   +2 more
wiley   +1 more source

Native and Engineered Extracellular Vesicles for the Treatment of Acute Lung Injury and Acute Respiratory Distress Syndrome

Small Science, EarlyView.
Both native and engineered extracellular vesicles (EVs) are served as promising therapeutic agents for treating acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). To circumvent the limitations of native EVs, various engineering strategies are adopted.
Zhengyan Gu, Wenjun Xue, Guanchao Mao, Zhipeng Pei, Jingjing Li, Mingxue Sun, Xinkang Zhang, Shanshan Zhang, Songling Li, Jinfeng Cen, Kai Xiao, Ying Lu, Qingqiang Xu   +12 more
wiley   +1 more source

Low‐Intensity Focused Ultrasound‐Responsive Nanobubbles Enhance Thrombus Targeting and Penetration for Highly Effective Thrombolytic Therapy

Small Structures, EarlyView.
Low‐intensity focused ultrasound (LIFU)‐responsive nanobubbles (PAF@M) specifically target thrombus sites and penetrate thrombi under LIFU stimulation. Meanwhile, the liquid–gas phase transition of perfluoropentane and the release of nitric oxide synergistically enhance ultrasonic cavitation to destroy thrombus structure, providing a safe and effective
Wenli Zhang, Maoyuan Sun, Lian Xu, Sijin Chen, Xiyue Rong, Junrui Wang, Jia Liu, Bo Liu, Jie Xu, Ying Luo, Qianying Du, Yi Wang, Yun Liu, Zhigang Wang, Haitao Ran, Dajing Guo   +15 more
wiley   +1 more source

The Biomaterial and Blood Clot Complex: A Crucial Early Environment for Osteo‐Coagulo‐Immunomodulation and the Advancement of Bone Biomaterials

Small Structures, EarlyView.
Various properties of bone biomaterials can modulate components of the blood clot (including the fibrin network, red blood cells, platelets, and the complement system) in vivo implantation, leading to the formation of a biomaterial–blood clot complex (BBCC) significantly impacting subsequent osteoimmunomodulation.
Zongpu Han, Jieyun Xu, Xinyu Guo, Lingyu Liang, Linjun Zhang, Yu Su, Wendong Gao, Qingming Tang, Lili Chen, Zhuofan Chen, Yin Xiao, Zetao Chen   +11 more
wiley   +1 more source

Intracavernosal platelet‐rich plasma therapy for erectile dysfunction: Current evidence and future directions

UroPrecision, EarlyView.
Abstract Erectile dysfunction (ED) is the inability to achieve or maintain an erection sufficient for satisfactory sexual performance, affecting over 50% of men aged 50 and older. ED is often linked to lifestyle factors and comorbidities, such as diabetes and cardiovascular disease.
Ahmed Ragheb
wiley   +1 more source