Results 131 to 140 of about 77,013 (219)

Unveiling the roles of extracellular vesicles in hematologic malignancies: Pathogenesis, diagnostic tools, and clinical translation

Interdisciplinary Medicine, EarlyView.
Extracellular vesicles play pivotal roles in both healthy hematopoiesis and hematologic malignancies. They not only regulate hematopoietic stem cell fitness but also drive cancer progression and drug resistance. Their clinical potential spans from serving as non‐invasive biomarkers to acting as innovative therapeutic platforms and drug delivery ...
Fengyu Chen, Zhiyuan Wu, Feng Zhang, Yuan Meng, Hongyan Liao, Tony Y. Hu   +5 more
wiley   +1 more source

The predictive value of platelet-to-lymphocyte ratio and lymphocyte count in recurrent small intestinal hemorrhage: a retrospective cohort study. [PDF]

BMC Gastroenterol
Han L, Jin Y, Liu Z, Zeng C, Chen Y.
europepmc   +1 more source

Immunomodulation of the Prostate Tumor Microenvironment Following Inorganic Arsenic Exposure

Journal of Applied Toxicology, EarlyView.
ABSTRACT The tumor microenvironment (TME) influences prostate cancer (PCa) progression through stromal and immune interactions. Adipose‐derived mesenchymal stromal cells (ASCs) modulate immune tone, while inorganic arsenic (iAs), a widespread toxicant, is linked to immune suppression and carcinogenesis.
Joseph J. Shearer, Cosette Rivera‐Cruz, Alexandre M. B. Cavalca, Carlos Eduardo Fonseca‐Alves, Marxa L. Figueiredo   +4 more
wiley   +1 more source

Platelet-to-lymphocyte ratio as a predictor of preoperative venous thrombosis in femoral fracture patients: a retrospective cohort study. [PDF]

Front Cardiovasc Med
Li K, Li D, Sun J.
europepmc   +1 more source

Single‐Cell Profiling Identifies CLEC5A+ Macrophages as Key Drivers of Thoracic Aortic Aneurysm Via CCL5‐Mediated M1 Polarization

Journal of Clinical Laboratory Analysis, EarlyView.
Thoracic aortic aneurysm (TAA) is a life‐threatening cardiovascular disease with limited therapeutic options. Through single‐cell RNA sequencing of aortic tissues from healthy individuals and TAA patients (105,541 cells), we identified CLEC5A+macrophages as the predominant pathogenic cell population exhibiting the highest M1 polarization score. Machine
Xiangyu Li, Chunguang Guo, Mingyao Luo, Chang Shu   +3 more
wiley   +1 more source

Irritable bowel syndrome is associated with novel inflammatory markers derived from hemogram parameters

Family Medicine & Primary Care Review, 2020
Gulali Aktas, Tuba Duman, Burcin Atak, Ozge Kurtkulagi, Satilmis Bilgin, Elif Basaran, Muhammed Demirkol, Mehmet Kosekli   +7 more
doaj   +1 more source

Prognostic Value of Platelet to Lymphocyte Ratio for Myocardial Infarction: A Systematic Review and Meta-Analysis. [PDF]

Clin Cardiol
Yu H, Li S, Wu Y, Ren X.
europepmc   +1 more source

Analysis of the Recovery of Immune Status in the Patients With Paroxysmal Nocturnal Hemoglobinuria After Treatment With C5 Complement Inhibitor

Journal of Clinical Laboratory Analysis, EarlyView.
We retrospectively evaluated the impact of C5 complement inhibition on immune cell profiles and recovery in 27 PNH patients; both CD4+ and CD8+ T cells exhibited partial recovery, while B cell counts increased but remained below normal levels. In contrast, Treg cells were significantly reduced in PNH patients and showed no notable change post‐treatment.
Hui Liu, Mengting Che, Liyan Li, Honglei Wang, Chaomeng Wang, Junshu Wu, Yingying Chen, Zhaoyun Liu, Lijuan Li, Rong Fu   +9 more
wiley   +1 more source

Neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio as prognostic factors in patients with colorectal cancer: a retrospective study. [PDF]

Front Med (Lausanne)
El Muhtaseb MS, Ismail LN, Haddad TA, Ghanayem H, Qudah S, Al Aruri DO, Abufaraj M.   +6 more
europepmc   +1 more source

Lipid Interference Flagging and Haemoglobin Correction in Lipemic Samples With a Hematology Analyzer

Journal of Clinical Laboratory Analysis, EarlyView.
A flagging method was developed based on the changes of routine blood parameters and blood cell scattergram. It highlights the clinical value of the “Lipid Particles?” flag in effectively identifying lipid interference. This study supports the use of HGB‐O measured by ERP channel as a robust tool for improving diagnostic accuracy in lipid interference ...
Yinhua Fan, Yimin Shen, Dongmei Liu, Yong Wang, Jun Cao, Bo Zhao, Yushuai Ma, Zijie Chen, Shuaishuai Zhang   +8 more
wiley   +1 more source