Results 181 to 190 of about 77,013 (219)

Safety Evaluation of an Aqueous Root and Leaf Extract of Ashwagandha (Withania somnifera)

open access: yesPhytotherapy Research, EarlyView.
Sensoril, an aqueous root and leaf extract of ashwagandha showed no evidence of mutagenicity in the in vitro Ames assay, was negative in the in vitro micronucleus, in vivo mammalian bone marrow chromosome aberration assays, and was well tolerated in the rat at up to 4000 mg/kg BW/day when administered orally for a period of 90 days. The data from these
Mukesh Summan   +2 more
wiley   +1 more source

Flavonoids in Nasal Therapeutics: Biological Activities, Delivery Challenges, and Formulation Strategies–A Systematic Review

open access: yesPhytotherapy Research, EarlyView.
Overview of the therapeutic potential of flavonoids in nasal delivery systems, highlighting their benefits to the human nasal cavity, and applications in the treatment of respiratory and brain‐related diseases. ABSTRACT Flavonoids represent a significant group of secondary metabolites.
Jeniffer Viviana Ramirez Hernández   +5 more
wiley   +1 more source

Age‐related clinical heterogeneity and peripheral T cell profile alterations in primary Sjögren's disease: A retrospective study of 5778 patients

open access: yesRheumatology &Autoimmunity, EarlyView.
This large‐scale retrospective study of 5778 primary Sjögren's disease (SjD) patients, stratified by diagnostic age, defines a distinct clinical and immunological profile for early‐diagnosed (<45 years) disease. We identified early diagnosis as an independent risk factor for hypergammaglobulinemia and interstitial lung disease, underpinned by a ...
Yuan Ning   +7 more
wiley   +1 more source

Predicting Failure at Initiation of High‐Flow Nasal Oxygen in Patients With COVID‐19: Literature Review, Development and Internal Validation of a Prediction Model

open access: yesRespirology, EarlyView.
A prediction model was developed for high‐flow nasal oxygen (HFNO) failure in acute hypoxemic patients with COVID‐19 pneumonia using predictors available prior to HFNO initiation. This stable and good‐performing model can assist in clinical decision‐making at a critical point, aiding timely intervention for patients at risk of HFNO failure.
Daphne J. T. Sjauw   +31 more
wiley   +1 more source

Role of sleep apnea‐specific hypoxic burden and sleep breathing impairment index in assessing cognitive impairment in obstructive sleep apnea adults

open access: yesSleep Research, EarlyView.
Abstract Purpose This study aimed to analyze the effectiveness of sleep apnea‐specific hypoxic burden (SASHB) and sleep disordered breathing index (SBII) in assessing cognitive dysfunction in adults with obstructive sleep apnea (OSA) and to compare them with the apnea‐hypopnea index (AHI).
Zitong Wang   +15 more
wiley   +1 more source

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