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Platelet-Activating Factor Antagonists
Annual Review of Pharmacology and Toxicology, 1987Over the past decade platelet-activating factor has achieved the status of an important inflammatory mediator. The scientific enthusiasm and number of research investigators, publications, and meetings recently devoted to PAF suggest that this mediator will be the subject of continued study in the foreseeable future.
R N Saunders, D A Handley
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Platelet Activating Factor and Platelets
1999Among agents which activate platelets PAF is unique since it is the only phospholipid known to date which stimulates platelets at nanomolar range. The first indications of such a mediator dates back to 1966 when it was observed that a mixture of rabbit platelets and stimulated leukocytes released histamine on specific antigen challenge (Barbaro and ...
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Science, 1984
Platelet-activating factor (PAF), a naturally occurring phospholipid, is a potent activator of various biological processes, including platelet aggregation.
E. Kornecki, Y. Ehrlich, R. Lenox
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Platelet-activating factor (PAF), a naturally occurring phospholipid, is a potent activator of various biological processes, including platelet aggregation.
E. Kornecki, Y. Ehrlich, R. Lenox
semanticscholar +1 more source
Platelet Activating Factor Receptors
2003Platelet activating factor (PAF) is a potent pro-inflammatory lipid mediator. Its effects are mediated through cell surface G protein-coupled receptors (GPCRs) that are distributed on numerous cells notably on endothelium [1]. An intracrine mode of action for PAF is proposed based on evidence for intracellular PAF binding sites [2] and retention of ...
Sanaa Choufani +15 more
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Desensitization of human platelets by platelet activating factor
Biochemical and Biophysical Research Communications, 1985Human platelets are less responsive to PAF at 37 degrees than at 25 degrees. They can be desensitized to the effects of PAF by pre-exposure to small concentrations. In both cases desensitization appears to be accompanied by a decreased affinity of the high affinity site for PAF rather than loss of binding sites.
Carolyn M. Chesney +2 more
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Platelet Microparticles: A Carrier of Platelet-Activating Factor?
Biochemical and Biophysical Research Communications, 1996Platelet-activating factor (PAF) has been considered to be released in a soluble form from activated platelets. Also a considerable number of microparticles were released from stimulated platelets. To evaluate the possibility that microparticles contain PAF, the amount of PAF in whole activated platelets, microparticles and the suspending medium was ...
Hideo Ariyoshi +4 more
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Synthesis of platelet-activating factor by human monocytes stimulated by platelet-activating factor
Journal of Allergy and Clinical Immunology, 1991The capacity of platelet-activating factor (PAF) to stimulate its own synthesis by human monocytes was examined. Adherent human monocytes of greater than 85% purity were incubated with 100 fM to 10 nM of PAF in the presence of 20 microCi of [3H]acetic acid to radiolabel newly synthesized PAF.
Frank H. Valone, Frank H. Valone
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1995
Platelet activating factor (PAF) is a low molecular weight, ether-linked phospholipid originally identified as a soluble factor, released from sensitized rabbit basophils during IgE anaphylaxis, that was capable of aggregating rabbit platelets [1, 2]. Cellular sources of PAF subsequently identified include neutrophil [3–8] and eosinophil granulocytes ...
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Platelet activating factor (PAF) is a low molecular weight, ether-linked phospholipid originally identified as a soluble factor, released from sensitized rabbit basophils during IgE anaphylaxis, that was capable of aggregating rabbit platelets [1, 2]. Cellular sources of PAF subsequently identified include neutrophil [3–8] and eosinophil granulocytes ...
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Platelet-activating factor acetylhydrolase
Prostaglandins & Other Lipid Mediators, 2002Platelet-activating factor (PAF) is one of the most potent lipid mediators and is involved in a variety of physiological events. The acetyl group at the sn-2 position of its glycerol backbone is required for its biological activity, and deacetylation of PAF induces loss of activity. The deacetylation reaction is catalyzed by PAF-acetylhydrolase (PAF-AH)
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