Results 261 to 270 of about 470,674 (313)
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Platelet Activation and Atherothrombosis
New England Journal of Medicine, 2007This review of the role of platelets in atherothrombosis illuminates the surprisingly numerous activities of these tiny, anucleate cells and stresses their participation in the inflammatory component of atherothrombosis. The information is presented in the context of the prevention of atherothrombosis by antiplatelet agents now in clinical use.
DAVI', Giovanni, PATRONO C.
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Platelet Activity in Washed Platelet Concentrates
Anesthesia & Analgesia, 2004Life-threatening anaphylaxis or febrile nonhemolytic transfusion reactions after transfusion of platelet concentrates (PCs) is a serious clinical problem caused by the sensitizing of recipients to plasma components, such as immunoglobulin A, or by cytokines. There is a possible indication for washing of PCs in these thrombocytopenic patients.
Schoenfeld H +4 more
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Platelet antithrombin activity
Thrombosis Research, 1980Abstract Platelets were studied for the presence of antithrombin (thrombin amidolytic inhibitory) activity. Platelet rich plasma contained more antithrombin activity than platelet poor plasma. This activity could be washed from a platelet pellet. Antithrombin activity increased on sonication of platelets but not following aggregation.
E E, Czapek, H C, Kwaan
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Platelet Activation in Psoriasis
Thrombosis and Haemostasis, 1985SummaryRecent epidemiological studies have suggested that psoriasis represents a risk factor for thrombotic vascular diseases. In order to evaluate the possible role of hemostatic changes in the development of thrombotic episodes in psoriasis, some parameters of the hemostatic “balance” were investigated in 22 male psoriatic patients and compared to ...
M, Berrettini +4 more
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Blood, 2009
To the editor: Protein kinase C (PKC) is a central regulator of platelet activation, and individual PKC isoforms are likely to have distinct roles.[1][1] We and others had previously reported roles for the novel PKC isoform, PKCθ, in integrin signaling[2][2] and platelet function.[3][3] The ...
Matthew T, Harper, Alastair W, Poole
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To the editor: Protein kinase C (PKC) is a central regulator of platelet activation, and individual PKC isoforms are likely to have distinct roles.[1][1] We and others had previously reported roles for the novel PKC isoform, PKCθ, in integrin signaling[2][2] and platelet function.[3][3] The ...
Matthew T, Harper, Alastair W, Poole
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Platelets and Plasminogen Activation
Thrombosis and Haemostasis, 1995Platelets serve as a site for assembly of the proteins of the plasminogen activator system. Once bound to the platelet surface, tissue-type plasminogen activator manifests enhanced catalytic activity. Plasmin, once formed, also binds to the platelets surface and, at low concentrations, renders the platelet dysfunctional by cleaving glycoprotein IIIa ...
J, Loscalzo +3 more
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Platelet activation in preeclampsia
American Journal of Obstetrics and Gynecology, 1985Platelet activation was assessed in hospitalized third-trimester patients with preeclampsia (n = 11) or chronic hypertension with superimposed preeclampsia (n = 11) and in healthy outpatient pregnant controls (n = 10) by measuring plasma beta-thromboglobulin, platelet factor 4, the platelet aggregate ratio, and the amount of collagen required to ...
M L, Socol +4 more
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The Coagulant Activity of Platelets
British Journal of Haematology, 1968When platelet‐rich plasma is incubated for 16–20 hours at 37° C. and the platelets are then separated and washed, tissue‐factor activity develops in these platelets. The active platelets accellerate the clotting of plasma samples deficient in Factor XII, XI, IX or VIII, and of normal plasma; the coagulant activity for samples deficient in Factors V ...
R, Biggs +3 more
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2007
Platelet-activating factor (PAF) is a potent mediator that occurs at very low concentrations in cells and tissues. Accurate quantitation of PAF has always been difficult because of the physicochemical properties of PAF and its structural similarity to several much more abundant phospholipids.
John S, Owen +2 more
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Platelet-activating factor (PAF) is a potent mediator that occurs at very low concentrations in cells and tissues. Accurate quantitation of PAF has always been difficult because of the physicochemical properties of PAF and its structural similarity to several much more abundant phospholipids.
John S, Owen +2 more
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Platelet antiaggregate activity
American Heart Journal, 1991Calcium ions act as a second messenger to platelet agonists, with increases in intracellular calcium bringing about changes in shape, aggregation, and release reactions. Changes in platelet function have been reported previously in migraine sufferers and there is evidence that hyperaggregability occurs during a migraine attack. It was decided to assess
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