Results 31 to 40 of about 5,845 (290)
Haematologica, 2010 Background Abnormal adhesiveness of red blood cells to endothelium has been implicated in vaso-occlusive crisis of sickle cell disease. The present study examined whether the SAD mouse model exhibits the same abnormalities of red blood cell adhesion as ...
Marie-Marcelle Trinh-Trang-Tan +4 more
doaj +1 more source
The Scientific World Journal, 2013 We studied the possible effect of flaxseed to prevent leukocytes and platelets adhesion to endothelial cells and to reduce soluble adhesion molecules (sVCAM-1) and endothelial integrity markers (vWF) in ovariectomized rats fed a high-fat diet.
Raluca Ecaterina Haliga +3 more
doaj +1 more source
Platelet adhesion in hypertension: Application of a novel assay of platelet adhesion
Annals of Medicine, 2005 The increased risk of thromboembolism in hypertension may be related to a prothrombotic or hypercoagulable state, with abnormalities in haemostasis and platelet function.To investigate the role of platelets in the pathogenesis of thrombosis in hypertension, we applied a novel new assay to detect and quantify the degree of platelet adhesion to a defined
Sunil K, Nadar +3 more
openaire +2 more sources
Hematological changes in postmenopausal women
National Journal of Physiology, Pharmacy and Pharmacology, 2019 Background: Ovarian function declines subsequent to menopause. This can lead to undesirable alterations in metabolism, vascular endothelium function, and also fibrinolytic and coagulative properties of blood.
Madhavi Kulkarni, Shaktiprasad Hiremath
doaj +1 more source
Translating proof-of-concept for platelet slip into improved antithrombotic therapeutic regimens
PlateletsPlatelets are central to thrombosis. Research at the intersection of biological and physical sciences provides proof-of-concept for shear rate-dependent platelet slip at vascular stenosis and near device surfaces.
Scott J. Denardo +6 more
doaj +1 more source
Scientific Reports, 2017 Sepsis causes multiple organs failures and eventually death. Changes in blood constituents due to sepsis lead to alterations in hemorheological properties, and cell adhesiveness.
Eunseop Yeom +5 more
doaj +1 more source
Cell Transplantation, 2017 CD34 + progenitor cells are growing in use for vascular repair. However, in diabetic individuals with cardiovascular diseases, these cells have dysfunctional engraftment capabilities, which compromise their use for autologous cell therapy.
Sylvie Cointe +8 more
doaj +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source