Results 161 to 170 of about 235,538 (306)

Remodeling the Physicochemical and Pharmacokinetic Properties of PROTAC via Lipid Nanodisks for Cancer Therapy

open access: yesAdvanced Science, EarlyView.
To solve the challenge of PROTACs in clinical potential due to poor water solubility and membrane permeability, a nanodelivery system based on lipid nanodisks loaded with MZ1 prodrug (LND‐MZ1) to remodel the physicochemical and pharmacokinetic properties of PROTAC MZ1 is elaborately proposed.
Meichen Pan   +6 more
wiley   +1 more source

ORL@Cu‐MOF Boost Cuproptosis and Suppress Fatty Acid Metabolism for Cancer Lymph Node Metastasis Synergistic Therapy

open access: yesAdvanced Science, EarlyView.
The fabrication of ORL@Cu‐MOF and the mechanism of synergistic therapy by cuproptosis, reprogram fatty acid metabolism and anti‐PD‐1. Abstract Lymph node metastasis (LNM) is one of the significant characteristics of poor prognosis in oral squamous cell carcinoma (OSCC), strongly associated with high mortality rates.
Zi‐Zhan Li   +11 more
wiley   +1 more source

A Modified Counting Method for Very Small Number of Residual White Blood Cells in Platelet Concentrates by Flow Cytometory.

open access: bronze, 1997
Mitsunobu Tanaka   +6 more
openalex   +2 more sources

Mesoporous Gold Nanospheres Confined Platinum Nanoclusters as Robust ROS and Oxygen Nanogenerators for NIR‐II Hyperthermia Cancer Therapy

open access: yesAdvanced Science, EarlyView.
Mesoporous gold nanospheres confined platinum nanoclusters (MGNSs@Pt) is developed as robust hydroxyl radical and oxygen nanogenerators for multimodal therapies. Their NIR‐II LSPR property also allowed MGSNs to be ideal phototheranostic agents. The chemodynamic and photothermal therapy efficiently induced the tumor cell apoptosis, enabling the MGNSs@Pt
Fei Cun   +7 more
wiley   +1 more source

Characteristics of the post-surgical decrease in platelet counts in orthopedic surgery patients, observations and insights

open access: yesHematology, Transfusion and Cell Therapy
Introduction: A reduced platelet count (PLT) is a frequent post-operative finding in orthopedic surgery patients. Despite its prevalence, the characteristics of post-surgical thrombocytopenia have not been well described.
George Zacharia   +5 more
doaj  

α-Actinin-1 deficiency in megakaryocytes causes low platelet count, platelet dysfunction, and mitochondrial impairment. [PDF]

open access: yesBlood Adv
Lin X   +19 more
europepmc   +1 more source

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