Results 161 to 170 of about 235,538 (306)
To solve the challenge of PROTACs in clinical potential due to poor water solubility and membrane permeability, a nanodelivery system based on lipid nanodisks loaded with MZ1 prodrug (LND‐MZ1) to remodel the physicochemical and pharmacokinetic properties of PROTAC MZ1 is elaborately proposed.
Meichen Pan+6 more
wiley +1 more source
Letter to the Editor on "The associations among platelet count, mean platelet volume, and erectile dysfunction: an observational and Mendelian randomization study". [PDF]
Fang Y, Chen S, Huang C, Cheng B.
europepmc +1 more source
The fabrication of ORL@Cu‐MOF and the mechanism of synergistic therapy by cuproptosis, reprogram fatty acid metabolism and anti‐PD‐1. Abstract Lymph node metastasis (LNM) is one of the significant characteristics of poor prognosis in oral squamous cell carcinoma (OSCC), strongly associated with high mortality rates.
Zi‐Zhan Li+11 more
wiley +1 more source
Bidirectional relationship between platelet count and skin cancer: tumor drug resistance mechanisms. [PDF]
Guo C+5 more
europepmc +1 more source
Mesoporous gold nanospheres confined platinum nanoclusters (MGNSs@Pt) is developed as robust hydroxyl radical and oxygen nanogenerators for multimodal therapies. Their NIR‐II LSPR property also allowed MGSNs to be ideal phototheranostic agents. The chemodynamic and photothermal therapy efficiently induced the tumor cell apoptosis, enabling the MGNSs@Pt
Fei Cun+7 more
wiley +1 more source
Introduction: A reduced platelet count (PLT) is a frequent post-operative finding in orthopedic surgery patients. Despite its prevalence, the characteristics of post-surgical thrombocytopenia have not been well described.
George Zacharia+5 more
doaj
α-Actinin-1 deficiency in megakaryocytes causes low platelet count, platelet dysfunction, and mitochondrial impairment. [PDF]
Lin X+19 more
europepmc +1 more source