Results 231 to 240 of about 976,634 (303)

Context‐Dependent Inverse Association of Glucose–Lipid Metabolic Status With Anemia: Evidence From Multinational Multicohort Analyses

Advanced Science, EarlyView.
Across six multinational cohorts, higher triglyceride–glucose index values are consistently associated with lower prevalent and incident anemia, despite their established adverse cardiometabolic significance. This inverse relationship varies across inflammatory, cardiovascular, and renal contexts, suggesting that glucose–lipid metabolic status carries ...
Guosong Jiang, Xinxing Wang, Lianfeng Xie, Wenna Ding, Yingyong Yin, Mei Yao, Zhibo Cui, Kaiqiang Tang, Lijie Zhong, Zhi Wang, Jia Wang, Lei Lei, Xiaoxiao Qu, Chi‐E. Qiu   +13 more
wiley   +1 more source

Association of Baseline Platelet Count with Complete Remission, Severe Bleeding, and 24-Month Overall Survival in Patients with Newly Diagnosed Acute Myeloid Leukemia: A Multi-Center Retrospective Cohort Study. [PDF]

Mediterr J Hematol Infect Dis
Zhou T, Ni Z, Fan W, Xu J, Qin J, Wang K, Wang R, Li Y.   +7 more
europepmc   +1 more source

NCOA4 Accelerates Abdominal Aortic Aneurysm Formation by Regulating Macrophage Activation and Ferroptosis via STAT1–CH25H Axis

Advanced Science, EarlyView.
Under pathological stimulation, NCOA4 in macrophages interacts with STAT1 to promote CH25H transcription. The subsequent increase in 25‐HC production activates macrophages, triggers inflammatory responses and ferroptosis, and accelerates the progression of AAA.
Zhinan Wu, Yuxuan Qian, Wenyi Xu, Fei Liao, Xueliang Liu, Xiao Kuang, Guqing Luo, Xinjie He, Lixian Jiang, Song Ding   +9 more
wiley   +1 more source

Esophageal Variceal Grading and Platelet Count in Patients With Liver Cirrhosis. [PDF]

Cureus
Farooq M, Sadiq U, Wadud Q, Ali A, Khawar Rahman D, Imran M, Safeer M, Habib SH, Habib TS.   +8 more
europepmc   +1 more source

CD112 Lactylation Drives Dual Immune Evasion From CD8+ T Cells and NK Cells

Advanced Science, EarlyView.
AARS2 functions as an intracellular lactate sensor and lactyltransferase, catalyzing CD112 K412 lactylation to block ubiquitination‐dependent degradation and stabilize CD112. This pathway suppresses CD8+ T‐cell and NK‐cell cytotoxicity, enabling dual immune evasion.
Zhuoshuo Xu, Xinyu Zhang, Fang Dong, Nenghao Shen, Jun Zhou, Zihan Xi, Zhenghao Wu   +6 more
wiley   +1 more source

Platelet count and clinical outcomes in hospitalized patients with COVID-19 pneumonia. [PDF]

Front Med (Lausanne)
Siniscalchi C, Di Micco P, Guerra A, Simoni R, Magro J, Parise A, Cerundolo N, Imbalzano E, Tana C, Finardi L, Meschi T.   +10 more
europepmc   +1 more source

Sonogenetic Control of Engineered Probiotics for the Treatment of MASH by Modulating the Gut‐Liver Axis

Advanced Science, EarlyView.
Researchers developed an engineered probiotic encapsulated in an inulin hydrogel, enabling ultrasound‐triggered intestinal delivery of IL‐22. In MASH model mice, this system remodeled gut microbiota, strengthened the intestinal barrier and reduced portal LPS and hepatic IL‐6.
Chunya Ji, Yan Fang, Shen Zhang, Weichen Xu, Wenyun Guo, Jing Chen, Mingrui Zhu, Congjian Wen, Siming Chen, Yuli Zhu, Huixiong Xu, Haohao Yin   +11 more
wiley   +1 more source

Optimal Sunitinib Dosing Based on Platelet Count in an Older Patient With Gastrointestinal Stromal Tumor. [PDF]

In Vivo
Suto H, Kawamura M, Morita M, Sakai H, Onoe T, Ikeuchi K, Matsumoto K.   +6 more
europepmc   +1 more source

scH16S‐Seq Maps Klebsiella pneumoniae‐Associated Myeloid States and Reveals a CD38–NAD Immunometabolic Axis That Impairs Lysosomal Acidification in Sepsis

Advanced Science, EarlyView.
Single‐cell host–bacterial 16S co‐sequencing (scH16S‐seq) integrates cell‐associated bacterial 16S‐derived signals with host transcriptomes to resolve bacterial signal‐enriched myeloid states in Klebsiella pneumoniae sepsis. Complementary pharmacological and genetic analyses define a CD38–NAD immunometabolic axis connecting mitochondrial bioenergetic ...
Yangguang Li, Yilong Yu, Fang Qin, Shenxing Li, Xuanheng Li, Peizhao Liu, Juanhan Liu, Haiqing Liu, Songqi Jing, Jianghao Zou, Sicheng Li, Jiayang Li, Tao Zheng, Yun Zhao, Jianan Ren, Xiuwen Wu   +15 more
wiley   +1 more source