Results 1 to 10 of about 6,659 (141)

Antiplatelet antibody predicts platelet desialylation and apoptosis in immune thrombocytopenia

Haematologica, 2022
Immune thrombocytopenia (ITP) is a bleeding disorder caused by dysregulated B- and T- cell functions, which lead to platelet destruction. A well-recognized mechanism of ITP pathogenesis involves anti-platelet and anti-megakaryocyte antibodies ...
Shiying Silvia Zheng, Zohra Ahmadi, Halina Hoi Laam Leung, Rose Wong, Feng Yan, Jose Sail Perdomo, Beng Hock Chong   +6 more
doaj   +1 more source

Application of Auxiliary VerifyNow Point-of-Care Assays to Assess the Pharmacodynamics of RUC-4, a Novel αIIbβ3 Receptor Antagonist

TH Open, 2021
Introduction Prehospital therapy of ST-elevation myocardial infarction (STEMI) with αIIbβ3 antagonists improves clinical outcomes, but they are difficult to use in prehospital settings.
Ohad S. Bentur, Jihong Li, Caroline S. Jiang, Linda H. Martin, Dean J. Kereiakes, Barry S. Coller   +5 more
doaj   +1 more source

Primary percutaneous transluminal coronary angioplasty in the acute infarction of the right ventricle [PDF]

Vojnosanitetski Pregled, 2003
Background. Predilection site for the acute myocardial infarction of the right ventricle, (AMI-RV) is the upper third of the right coronary artery and for this reason such an infarction is followed by numerous complications, primarily by conduction ...
Gligić Branko, Orozović Vjekoslav, Obradović Slobodan, Rusović Siniša, Kostić Jelena, Baškot Branislav, Dinčić Dragan, Ristić-Anđelkov Anđelka   +7 more
doaj   +1 more source

Identification of one novel pathogenic ITGB3 mutation and two known mutations in two Chinese pedigrees with hereditary Glanzmann thrombasthenia

Platelets, 2020
Glanzmann thrombasthenia (GT) is an inherited disorder of platelet aggregation resulting from quantitative and/or qualitative abnormalities of the glycoprotein IIb/IIIa complex.
Zhengjing Lu, Lauriane Nikuze, Zhoulin Zhong, Fang Li, Fuyong Zhang, Kairong Liang, Manlv Wei, Hongying Wei   +7 more
doaj   +1 more source

Platelet surface marker analysis by mass cytometry

Platelets, 2020
Mass cytometry is a next generation flow cytometry technology which analyzes cells one at a time (up to 1000/sec) using mass spectrometry to detect probes labeled with rare-earth metals.
Thomas A. Blair, Andrew L. Frelinger
doaj   +1 more source

Investigation of interaction of human platelet membrane components with anticoagulant drugs Abciximab and Eptifibatide.

Folia Histochemica et Cytobiologica, 2011
Abciximab (Abci) and eptifibatide (Epti) are antiaggregate drugs which may reduce thrombotic complications in acute coronary syndromes. The aim of this work was the investigation of the interaction between the phospholipid-GPIIb/IIIa glycoprotein complex
Anna Sankiewicz, Ewa Gorodkiewicz, Zbigniew A Figaszewski   +2 more
doaj   +1 more source

Estudo experimental do uso de um antagonista do receptor da glicoproteína IIb/IIIa das placentas na prevenção de tromboses em microanastomoses vasculares An experimental study on the use of an antagonist of the platelet glycoprotein IIb/IIIa receptor in the prevention of thrombosis in vascular microanastomoses

Acta Ortopédica Brasileira, 2000
O autor comparou, experimentalmente, a eficácia da droga abciximab, um antagonista do receptor da glicoproteína IIb/IIIa das plaquetas, na prevenção da trombose nas microanastomoses arteriais em ratos Wistar.
Márcio Issamu Oide
doaj   +1 more source

In Vitro Comparison of Device‐Induced Hemolysis, Platelet Defects, and von Willebrand Factor Degradation Between the HeartMate 2 and HeartMate 3 Pumps

Artificial Organs, EarlyView.
This in vitro comparative study demonstrated that the HeartMate 3 pump has a superior overall hemocompatibility profile to the HeartMate 2 pump, underscoring the advantages of the maglev centrifugal pump design compared to the axial pump design. ABSTRACT Background Left ventricular assist devices (LVADs) have been utilized to maintain the circulatory ...
John Vandenberge, Dong Han, Wenji Sun, Shigang Wang, Douglas Tran, Nancy Kim, Kiersten Clark, Randy Perez, Bartley P. Griffith, Zhongjun J. Wu   +9 more
wiley   +1 more source

Gene mutations of platelet glycoproteins and response to tirofiban in acute coronary syndrome

São Paulo Medical Journal
CONTEXT AND OBJECTIVES: Glycoprotein inhibitors (abciximab, eptifibatide and tirofiban) are used in patients with unstable angina and non-ST-segment elevation myocardial infarction before percutaneous coronary intervention.
Antonio de Padua Mansur, Alessandra Roggerio, Júlio Yoshio Takada, Pérola Michelle Vasconcelos Caribé, Solange Desirée Avakian, Célia Maria Cassaro Strunz   +5 more
doaj   +1 more source

Selatogrel: Potential to redefine timely anti‐platelet intervention

British Journal of Pharmacology, Volume 182, Issue 22, Page 5435-5452, November 2025.
Acute coronary syndrome (ACS) encompasses a number of heart diseases that cause a sudden decrease in coronary perfusion, precipitating cardiomyocyte necrosis or heightened risk thereof. This pathology is a major burden of cardiovascular disease.
Rudy N. Zalzal, Peter P. Salem, Ali H. Dakroub, Ali H. Eid   +3 more
wiley   +1 more source