Results 11 to 20 of about 6,659 (141)

Quantitation of platelet‐specific autoantibodies in platelet eluates of ITP patients measured by a novel ELISA using the purified glycoprotein complexes GPIIb/IIIa and GPIb/IX as antigens [PDF]

British Journal of Haematology, 1997
Immune thrombocytopenic purpura (ITP) is a disorder caused by anti‐platelet autoantibodies (Ab), most of which are directed against epitopes on platelet membrane glycoprotein complexes GPIIb/IIIa and GPIb/IX. To detect platelet Ab, reliable techniques, such as MAIPA or immunobead assay, have been developed.
Marianne Hürlimann‐Forster, Beat Steiner, A. von Felten   +2 more
openalex   +4 more sources

Circulating Microclots Are Structurally Associated With Neutrophil Extracellular Traps and Their Amounts Are Elevated in Long COVID Patients

Journal of Medical Virology, Volume 97, Issue 10, October 2025.
ABSTRACT The persistence of vasculo‐thrombotic complications has been put forward as a possible contributing factor in the Long COVID (LC) syndrome. Given the recently reported separate demonstration of the association of LC with elevated levels of heterogenous fibrin(ogen) amyloidogenic particles (microclots) and with those neutrophil extracellular ...
Alain R. Thierry, Tom Usher, Cynthia Sanchez, Simone Turner, Chantelle Venter, Brice Pastor, Maxine Waters, Anel Thompson, Alexia Mirandola, Ekaterina Pisareva, Corinne Prevostel, Gert J. Laubscher, Douglas B. Kell, Etheresia Pretorius   +13 more
wiley   +1 more source

Preparation of cold‐stored platelets on‐demand: A novel approach to inventory management

Transfusion, Volume 65, Issue 10, Page 1903-1913, October 2025.
Abstract Background Cold‐stored platelets (CSP) are now being used to treat acute bleeding. However, as CSP are less suitable for prophylaxis, both room temperature (RT) platelets and CSP will be required, which complicates inventory management. The production of CSP “on‐demand” from RT platelets may be a desirable option.
Lacey Johnson, Lauren Waters, Christopher Roan, Pearl Lei, Janhavi Mahajan, Mailys Portier, Ben Winskel‐Wood, Denese C. Marks   +7 more
wiley   +1 more source

A Critical Review on BH3 Mimetic Drugs and the Treatment of Cancer‐Associated Thrombosis (CAT): A Proposed Design for a Drug Delivery System Capable of Simultaneously Targeting Tumor Cells and Activated Platelets

Cancer Medicine, Volume 14, Issue 18, September 2025.
Targeting Cancer associated thrombosis (CAT): The left panel (A) shows cancer‐associated thrombosis with activated platelets expressing αIIbβ3 in close contact with tumoral vasculature expressing αvβ3 integrin, where both cells release a significant amount of thrombin.
Mehran Ghasemzadeh, Nazanin Heidari, Jalal Naghinezhad, Alireza Ghasemzadeh, Ehteramolsadat Hosseini   +4 more
wiley   +1 more source

Periodontitis and Platelets Status: A Systematic Review With Meta‐Analysis and Trial Sequential Analysis

Journal of Periodontal Research, Volume 60, Issue 9, Page 872-888, September 2025.
The certainty is moderate for a slightly higher platelet count in patients with periodontitis compared to individuals without periodontitis and low for no difference in mean platelet volume between the two groups. The evidence is not robust to claim a clear difference in other platelet activation biomarkers between the two groups.
Dimitris Sokos, Marja L. Laine, Elena A. Nicu, Kelly Hiu Lam Chung, Ni‐ni Dong Qing Sluijk, Dagmar Else Slot, Sergio Bizzarro   +6 more
wiley   +1 more source

Investigation of interaction of human platelet membrane components with anticoagulant drugs Abciximab and Eptifibatide

Folia Histochemica et Cytobiologica, 2010
Abciximab (Abci) and eptifibatide (Epti) are antiaggregate drugs which may reduce thrombotic complications inacute coronary syndromes. The aim of this work was the investigation of the interaction between the phospholipid-GPIIb/IIIa glycoprotein complex ...
Ewa Gorodkiewicz, Anna Sankiewicz, Zbigniew A. Figaszewski   +2 more
doaj  

Increased Thrombogenicity is Associated With Coronary Microvascular Dysfunction in Patients With STEMI—A Proof‐of‐Concept Study

Catheterization and Cardiovascular Interventions, Volume 106, Issue 2, Page 836-845, August 1, 2025.
ABSTRACT Background Up to 50% of patients with ST‐segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (pPCI) develop coronary microvascular dysfunction (CMD). Aims This study aims to assess whether a prothrombotic state of coronary blood, defined by thromboelastography (TEG), is associated with post ...
Roberto Scarsini, Denis Leonardi, Andrea Bottardi, Concetta Mammone, Leonardo Portolan, Caterina Butturini, Verdiana Galli, Francesco Della Mora, Alessandro Ruzzarin, Sara Pazzi, Anna Piccoli, Simone Fezzi, Domenico Tavella, Gabriele Pesarini, Leonardo Gottin, Flavio Ribichini   +15 more
wiley   +1 more source

Surface Engineering of Thrombus‐Targeting Nanocarriers for Cardiovascular Diseases: A Short Review

Advanced Materials Interfaces, Volume 12, Issue 13, July 14, 2025.
This paper systematically introduces surface modification strategies for thrombus‐targeting nanocarriers, highlights the clinical significance of nanocarrier‐based thrombolysis therapies, and prospects the synergy of combing thrombolysis and anti‐inflammatory therapies for enhanced therapeutic effect.
Xinyue Ge, Lei Ding, Wenjun Zhao, Bohan Cui, Xiang Guan, Mingfei Pan, Qingguo Li, Ning Gu   +7 more
wiley   +1 more source

Highly Stable Aggregation‐Induced Emission‐Functionalized Histatin1 Coated With Platelet Vesicles for Diabetic Wound Healing

Aggregate, Volume 6, Issue 7, July 2025.
Diabetic wound healing is blocked by persistent inflammation and oxidative stress. Bioactive substances like growth factors and Hsts promote repair but lack long‐term stability. Herein, a platelet membrane‐coated nanoparticle system (PNP) is proposed to achieve enhanced retention of aggregation‐induced emissive (AIE) molecular‐modified Hst1 (Hst1‐AIE ...
Xiaoxuan Lei, Judun Zheng, Xu Chen, Liwen Liang, Zhuohong Li, Cancan Huang, Minghai Zhao, Gang Wu, Yuhui Liao, Bin Yang   +9 more
wiley   +1 more source

The Biomaterial and Blood Clot Complex: A Crucial Early Environment for Osteo‐Coagulo‐Immunomodulation and the Advancement of Bone Biomaterials

Small Structures, Volume 6, Issue 7, July 2025.
Various properties of bone biomaterials can modulate components of the blood clot (including the fibrin network, red blood cells, platelets, and the complement system) in vivo implantation, leading to the formation of a biomaterial–blood clot complex (BBCC) significantly impacting subsequent osteoimmunomodulation.
Zongpu Han, Jieyun Xu, Xinyu Guo, Lingyu Liang, Linjun Zhang, Yu Su, Wendong Gao, Qingming Tang, Lili Chen, Zhuofan Chen, Yin Xiao, Zetao Chen   +11 more
wiley   +1 more source