Results 41 to 50 of about 6,861 (145)

The Pl(A2) polymorphism of integrin beta(3) enhances outside-in signaling and adhesive functions. [PDF]

, 2000
Genetic factors are believed to influence the development of arterial thromboses. Because integrin alpha(IIb)beta(3) plays a crucial role in thrombus formation, we analyzed receptor adhesive properties using Chinese hamster ovary and human kidney ...
Ardissino, Bennett, Bennett, Bray, Bray, Carter, Christine Roos, Defilippi, Faraday, Felgner, Feng, Gunning, Haimovich, Hall, Herrmann, K. Vinod Vijayan, Kim, Kornecki, Lefkovits, Leng, Marguerie, Moskowitz, O’Toole, O’Toole, Pascal J. Goldschmidt-Clermont, Paul F. Bray, Ridker, Roos, Rosa, Sohn, Suehiro, Valentin, Van Leeuwen, Vijayan, Walter, Weiss, Weiss   +36 more
core   +3 more sources

Circulating Microclots Are Structurally Associated With Neutrophil Extracellular Traps and Their Amounts Are Elevated in Long COVID Patients

Journal of Medical Virology, Volume 97, Issue 10, October 2025.
ABSTRACT The persistence of vasculo‐thrombotic complications has been put forward as a possible contributing factor in the Long COVID (LC) syndrome. Given the recently reported separate demonstration of the association of LC with elevated levels of heterogenous fibrin(ogen) amyloidogenic particles (microclots) and with those neutrophil extracellular ...
Alain R. Thierry, Tom Usher, Cynthia Sanchez, Simone Turner, Chantelle Venter, Brice Pastor, Maxine Waters, Anel Thompson, Alexia Mirandola, Ekaterina Pisareva, Corinne Prevostel, Gert J. Laubscher, Douglas B. Kell, Etheresia Pretorius   +13 more
wiley   +1 more source

Integrin-dependent control of translation: engagement of integrin alphaIIbbeta3 regulates synthesis of proteins in activated human platelets. [PDF]

, 1999
Integrins are widely expressed plasma membrane adhesion molecules that tether cells to matrix proteins and to one another in cell-cell interactions. Integrins also transmit outside-in signals that regulate functional responses of cells, and are known to ...
Bray, Paul F, Dixon, Dan A, McIntyre, Thomas M, Pabla, Ravinder, Prescott, Stephen M, Weyrich, Andrew S, Zimmerman, Guy A   +6 more
core   +1 more source

Cibles des médicaments antithrombotiques [PDF]

, 2006
Pour la quasi-totalité des classes thérapeutiques antithrombotiques actuellement utilisées et à venir, le ciblage a été initialement la conséquence d’une observation et non pas le fruit d’une recherche méthodique scientifique.
Drouet, Ludovic, Ripoll, Laurent
core   +1 more source

Preparation of cold‐stored platelets on‐demand: A novel approach to inventory management

Transfusion, Volume 65, Issue 10, Page 1903-1913, October 2025.
Abstract Background Cold‐stored platelets (CSP) are now being used to treat acute bleeding. However, as CSP are less suitable for prophylaxis, both room temperature (RT) platelets and CSP will be required, which complicates inventory management. The production of CSP “on‐demand” from RT platelets may be a desirable option.
Lacey Johnson, Lauren Waters, Christopher Roan, Pearl Lei, Janhavi Mahajan, Mailys Portier, Ben Winskel‐Wood, Denese C. Marks   +7 more
wiley   +1 more source

Randomized trial of a GPIIb/IIIa platelet receptor blocker in refractory unstable angina [PDF]

, 1994
BACKGROUND: Patients with unstable angina despite intensive medical therapy, ie, refractory angina, are at high risk for developing thrombotic complications: myocardial infarction or coronary occlusion during percutaneous transluminal coronary ...
Boer, M.J. (Menko Jan) de, Bono, D.P. (David) de, Brand, M.J.B.M. (Marcel) van den, Feyter, P.J. (Pim) de, Heyndrickx, G.R. (Guy), Hoorntje, J.C.A., Klootwijk, A.P.J. (Peter), Miltenburg-van Zijl, A.J.M. (Addy) van, Nijssen, K.M., Rutsch, W.R. (Wolfgang), Schaible, T.F., Simoons, M.L. (Maarten), Stibbe, J. (Jeanne), Weisman, H.F., Wieken, L.R. (Ron) van der   +14 more
core  

Recreation of the terminal events in physiological integrin activation. [PDF]

, 2010
Increased affinity of integrins for the extracellular matrix (activation) regulates cell adhesion and migration, extracellular matrix assembly, and mechanotransduction.
Bobkov, Andrey A, Ginsberg, Mark H, Hu, Guiqing, McLean, Mark A, Ratnikov, Boris, Sligar, Stephen G, Taylor, Dianne, Taylor, Kenneth A, Ye, Feng   +8 more
core   +3 more sources

A Critical Review on BH3 Mimetic Drugs and the Treatment of Cancer‐Associated Thrombosis (CAT): A Proposed Design for a Drug Delivery System Capable of Simultaneously Targeting Tumor Cells and Activated Platelets

Cancer Medicine, Volume 14, Issue 18, September 2025.
Targeting Cancer associated thrombosis (CAT): The left panel (A) shows cancer‐associated thrombosis with activated platelets expressing αIIbβ3 in close contact with tumoral vasculature expressing αvβ3 integrin, where both cells release a significant amount of thrombin.
Mehran Ghasemzadeh, Nazanin Heidari, Jalal Naghinezhad, Alireza Ghasemzadeh, Ehteramolsadat Hosseini   +4 more
wiley   +1 more source

Cu2+-RGDFRGDS: exploring the mechanism and high efficacy of the nanoparticle in antithrombotic therapy

International Journal of Nanomedicine, 2015
Jianhui Wu,1 Yuji Wang,1 Yaonan Wang,1 Ming Zhao,1,2 Xiaoyi Zhang,1 Lin Gui,1 Shurui Zhao,1 Haimei Zhu,1 Jinghua Zhao,1 Shiqi Peng11Beijing Area Major Laboratory of Peptide and Small Molecular Drugs, Engineering Research Center of Endogenous Prophylactic
Wu J, Wang Y, Wang Y, Zhao M, Zhang X, Gui L, Zhao S, Zhu H, Zhao J, Peng S   +9 more
doaj  

The role of platelet activation in tumor metastasis [PDF]

, 2008
Platelets are highly reactive components of the circulatory system, which exert not only haemostatic activity but also contribute to the modulation of various pathological conditions including inflammation, atherosclerosis and cancer metastasis through ...
Borsig, L
core   +1 more source