Platelet hyperreactivity: predictive and intrinsic properties. [PDF]
, 2007 Platelet thrombi are central to the development of most vascular ischemic events. There is marked interindividual variation in platelet responsiveness, with some subjects displaying platelet hyperreactivity.
Bray, Paul F
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Immunopathogenic mechanisms of Coronary Artery Disease and plaque destabilization [PDF]
, 2008 Inflammation seems to play a role in both the chronic atherosclerotic process as well as in plaque destabilization, leading to the development of acute coronary syndromes (ACS).
Smith, Camilla
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Stroke following percutaneous coronary intervention : type-specific incidence, outcomes and determinants seen by the British Cardiovascular Intervention Society 2007-12 [PDF]
, 2016 Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2015.
Berry, Colin +11 more
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Idiopathic thrombocytopenic purpura: current concepts in pathophysiology and management. [PDF]
, 2008 Idiopathic thrombocytopenic purpura (ITP) is characterized by a low platelet count, which is the result of both increased pla- telet destruction and insufficient platelet production.
Amadori, S +5 more
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Phosphorothioate backbone modifications of nucleotide-based drugs are potent platelet activators [PDF]
, 2015 Nucleotide-based drug candidates such as antisense oligonucleotides, aptamers, immunoreceptor-activating nucleotides, or (anti)microRNAs hold great therapeutic promise for many human diseases.
Advani +44 more
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The Effectiveness of Clopidogrel as an Antithrombotic Compared to Ticlopidine and Aspirin (Meta-analysis) [PDF]
, 2017 Clopidogrel, an antithrombotic drug, has been proven by FDA as Plavix® was initially used for the prevention of vascular occlusive that cause of myocardial infarction, stroke, and vascular death in patients with atherosclerosis and then it is used to ...
Hartayu, T. S. (Titien) +1 more
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Evaluación de la activación plaquetaria en la leucemia linfoblástica aguda [PDF]
, 2007 Objetivo. Investigar si los pacientes con LLA desarrollan un estado hipercoagulable con activación plaquetaria. Material y métodos. Se incluyeron quince pacientes con LLA de la infancia, trece de tipo B y dos de tipo T. El grupo control consistió de
Campos Cartagena, Verónica +4 more
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A novel role for the fibrinogen Asn-Gly-Arg (NGR) motif in platelet function. [PDF]
, 2014 The integrin αIIbβ3 on resting platelets can bind to immobilised fibrinogen resulting in platelet spreading and activation but requires activation to bind to soluble fibrinogen. αIIbβ3 is known to interact with the general integrin-recognition motif RGD (
Brennan, Marian +7 more
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Affinity modulation of platelet integrin alphaIIbbeta3 by beta3-endonexin, a selective binding partner of the beta3 integrin cytoplasmic tail. [PDF]
, 1997 Platelet agonists increase the affinity state of integrin alphaIIbbeta3, a prerequisite for fibrinogen binding and platelet aggregation. This process may be triggered by a regulatory molecule(s) that binds to the integrin cytoplasmic tails, causing a ...
Davis, KA +5 more
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Platelet signalling networks: pathways perturbation demonstrates differential sensitivity of ADP secretion and fibinogen binding. [PDF]
, 2011 Platelet signalling responses to single agonists have been identified previously. However a model of the total platelet signalling network is still lacking.
De Chaumont, Ciaran +3 more
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