Molecular Pathogenesis of Inherited Platelet Dysfunction [PDF]
BiomoleculesInherited platelet function disorders (IPFD) are characterized by normal platelet count and morphology but impaired function due to pathogenic variants in genes encoding membrane receptors, granule constituents, or intracellular signaling proteins ...
Agustín Rodríguez-Alén +3 more
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Association of Platelet Membrane Glycoprotein HPA-2a/b, GP VI T13254C, and GP Ibα VNTR Polymorphisms with Risk of Coronary Artery Disease: A Meta-Analysis. [PDF]
Biomed Res Int, 2017 Ni W, He J, Wang H, Liu T.
europepmc +3 more sources
Development of the Integrated Computer Simulation Model of the Intracellular, Transmembrane, and Extracellular Domain of Platelet Integrin αIIbβ3 (Platelet Membrane Glycoprotein: GPIIb–IIIa) [PDF]
TH OpenMasamitsu Nakayama +2 more
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Targeting macrophage endocytosis via platelet membrane coating for advanced osteoimmunomodulation
iScience, 2022 Summary: The identification, uptake, and clearance of nanoparticles (NPs) by phagocytes are critical in NP-based therapeutics. The cell membrane coating technique has recently emerged as an ideal surface modification approach to help NP bypass ...
Wendong Gao +3 more
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The basement membrane protein nidogen-1 supports platelet adhesion and activation
Platelets, 2021 The core structure of the extracellular basement membrane is made up of self-assembling networks of collagen and laminin which associate with each other through the bridging adapter proteins including the sulfated monomeric glycoprotein nidogen.
Hari Hara Sudhan Lakshmanan +12 more
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Frontiers in Pediatrics, 2022 Glanzmann thrombasthenia (GT) is a rare autosomal recessive platelet disorder due to a qualitative or quantitative anomaly of the platelet membrane glycoprotein GPIIb/IIIa. Its clinical manifestations include mild to severe bleeding.
Jian hua Li +9 more
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Haematologica, 2020 Platelet adhesion to the sub-endothelial matrix and damaged endothelium occurs through a multi-step process mediated in the initial phase by glycoprotein Ib binding to von Willebrand factor (vWF), which leads to the subsequent formation of a platelet ...
Simona Stivala +7 more
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The role of neuraminidase 1 and 2 in glycoprotein Ibα-mediated integrin αIIbβ3 activation
Haematologica, 2020 Upon vascular injury, platelets adhere to von Willebrand Factor (VWF) via glycoprotein Ibα (GPIbα). GPIbα contains many glycans, capped by sialic acid. Sialic acid cleavage (desialylation) triggers clearance of platelets.
Dianne E. van der Wal +3 more
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Antiplatelet antibody predicts platelet desialylation and apoptosis in immune thrombocytopenia
Haematologica, 2022 Immune thrombocytopenia (ITP) is a bleeding disorder caused by dysregulated B- and T- cell functions, which lead to platelet destruction. A well-recognized mechanism of ITP pathogenesis involves anti-platelet and anti-megakaryocyte antibodies ...
Shiying Silvia Zheng +6 more
doaj +1 more source
Journal of Interventional Cardiology, 2021 Aim. To predict platelet accumulation around stent struts in the presence or absence of tissue defects around them. Methods. Computer simulations were performed using virtual platelets implementing the function of the three membrane proteins ...
Yota Kawamura +3 more
doaj +1 more source