Analysis of Platelet Membrane Glycoproteins in Myeloproliferative Disorders [PDF]
Blood & Vessel, 1979 The platelet membrane glycoproteins (GP) of myeloproliperetion disorders(12 cases) were analyzed by SDS PAGE. In GP I peak there was no difference between normal and this disorders in the 125I incorporation rate but the percentage of GP I to all PAS stained peaks was reduced in chronic myelogenous leukemia (CML) but increased in primary thrombo ...
Kingo Fujimura +2 more
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Development of the Integrated Computer Simulation Model of the Intracellular, Transmembrane, and Extracellular Domain of Platelet Integrin αIIbβ3 (Platelet Membrane Glycoprotein: GPIIb–IIIa) [PDF]
TH OpenMasamitsu Nakayama +2 more
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The platelet membrane glycoprotein IIb-IIIa complex [PDF]
Blood, 1988 DR Phillips +3 more
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Targeting macrophage endocytosis via platelet membrane coating for advanced osteoimmunomodulation
iScience, 2022 Summary: The identification, uptake, and clearance of nanoparticles (NPs) by phagocytes are critical in NP-based therapeutics. The cell membrane coating technique has recently emerged as an ideal surface modification approach to help NP bypass ...
Wendong Gao +3 more
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The basement membrane protein nidogen-1 supports platelet adhesion and activation
Platelets, 2021 The core structure of the extracellular basement membrane is made up of self-assembling networks of collagen and laminin which associate with each other through the bridging adapter proteins including the sulfated monomeric glycoprotein nidogen.
Hari Hara Sudhan Lakshmanan +12 more
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Frontiers in Pediatrics, 2022 Glanzmann thrombasthenia (GT) is a rare autosomal recessive platelet disorder due to a qualitative or quantitative anomaly of the platelet membrane glycoprotein GPIIb/IIIa. Its clinical manifestations include mild to severe bleeding.
Jian hua Li +9 more
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Haematologica, 2020 Platelet adhesion to the sub-endothelial matrix and damaged endothelium occurs through a multi-step process mediated in the initial phase by glycoprotein Ib binding to von Willebrand factor (vWF), which leads to the subsequent formation of a platelet ...
Simona Stivala +7 more
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The role of neuraminidase 1 and 2 in glycoprotein Ibα-mediated integrin αIIbβ3 activation
Haematologica, 2020 Upon vascular injury, platelets adhere to von Willebrand Factor (VWF) via glycoprotein Ibα (GPIbα). GPIbα contains many glycans, capped by sialic acid. Sialic acid cleavage (desialylation) triggers clearance of platelets.
Dianne E. van der Wal +3 more
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Platelet membrane glycoproteins: historical perspectives [PDF]
Journal of Thrombosis and Haemostasis, 2006 3–9. The function of blood platelets to prevent blood loss at injured sites in the vasculature depends largely on their capacity to adhere, aggregate, promote coagulation and secrete factors that induce vasoconstriction and recruit inflammatory cells. Produced in large numbers from megakaryocytes, platelets enter the circulation for 7–10 days primed to
D. R. Phillips +2 more
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Antiplatelet antibody predicts platelet desialylation and apoptosis in immune thrombocytopenia
Haematologica, 2022 Immune thrombocytopenia (ITP) is a bleeding disorder caused by dysregulated B- and T- cell functions, which lead to platelet destruction. A well-recognized mechanism of ITP pathogenesis involves anti-platelet and anti-megakaryocyte antibodies ...
Shiying Silvia Zheng +6 more
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