The platelet membrane glycoprotein IIb-IIIa complex [PDF]
David R. Phillips+3 more
semanticscholar +7 more sources
Analysis of Platelet Membrane Glycoproteins in Myeloproliferative Disorders [PDF]
The platelet membrane glycoproteins (GP) of myeloproliperetion disorders(12 cases) were analyzed by SDS PAGE. In GP I peak there was no difference between normal and this disorders in the 125I incorporation rate but the percentage of GP I to all PAS stained peaks was reduced in chronic myelogenous leukemia (CML) but increased in primary thrombo ...
Kingo Fujimura+2 more
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Isolation and Quantitation of the Platelet Membrane Glycoprotein Deficient in Thrombasthenia Using a Monoclonal Hybridoma Antibody [PDF]
We used the hybridoma technique to characterize further the platelet glycoprotein abnormality in Glanzmann's thrombasthenia. Spleen cells from Balb/c mice immunized with human platelets were fused to mouse myeloma cell line Sp2/0-Ag14.
Rodger P. McEver+2 more
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The topographic relationships of platelet membrane glycoprotein IIb and glycoprotein IIIa have been studied in stimulated and unstimulated human platelets using immunoelectron microscopy.
Margaret J. Polley+3 more
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Structural analysis of human platelet membrane glycoprotein I complex.
The glycoprotein I complex, consisting of two polypeptides of Mr 210,000 and 150,000, was isolated from human platelet membranes by wheat germ lectin affinity chromatography.
Ralph L. Nachman+2 more
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Platelet binding by Streptococcus gordonii strain M99 is dependent on expression of the cell wall-anchored glycoprotein GspB. This large cell surface protein is exported from the M99 cytoplasm via a dedicated transport system that includes SecA2 and ...
Barbara A. Bensing+2 more
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Isolation and characterization of the major oligosaccharide of human platelet membrane glycoprotein GPIb. [PDF]
Treatment of intact human platelets with chymotrypsin released a glycopolypeptide that was shown to be derived from the major membrane glycoprotein, GPIb.
P. Judson, D. Anstee, John R. CLAMPt
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Engagement of platelet membrane glycoprotein (GP) Ib-IX-V by von Willebrand factor triggers Ca(++)-dependent activation of alphaIIbbeta3, resulting in (patho)physiological thrombus formation. It is demonstrated here that the cytoplasmic domain of GPIb-IX-
Robert K. Andrews+3 more
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Identification of the platelet-specific alloantigen, Naka, on platelet membrane glycoprotein IV [PDF]
Abstract We describe the membrane localization of a new platelet-specific alloantigen, designated Naka, that is involved in refractoriness to HLA- matched platelet transfusions. By indirect immunoprecipitation, anti- Naka antibody precipitated a single, radiolabeled platelet membrane protein with a molecular weight (mol wt) of 91 Kd from
S Sekiguchi+9 more
openaire +4 more sources
Development of the Integrated Computer Simulation Model of the Intracellular, Transmembrane, and Extracellular Domain of Platelet Integrin α IIb β 3 (Platelet Membrane Glycoprotein: GPIIb-IIIa). [PDF]
Nakayama M, Goto S, Goto S.
europepmc +2 more sources