Results 51 to 60 of about 83,070 (313)

Loss of Fibronectin Fiber Tension in Glioblastoma is Associated with Microvascular Proliferations and Immune Cell Infiltration

Advanced Science, EarlyView.
Researchers discovered that fibronectin fibers lose their tension in specific areas of glioblastoma brain tumors, accumulating in the lumen of proliferating blood vessels and in parenchyma next to infiltrating immune cell clusters. A novel molecular tension probe enables the mapping of fibronectin's fiber tension in glioblastoma for the first time ...
Michele Crestani, Isabel Gerber, Arnaud Mieville, Katrin Frauenknecht, Theoni Maragkou, Tibor Hortobagyi, Viola Vogel   +6 more
wiley   +1 more source

Investigation of interaction of human platelet membrane components with anticoagulant drugs Abciximab and Eptifibatide

Folia Histochemica et Cytobiologica, 2010
Abciximab (Abci) and eptifibatide (Epti) are antiaggregate drugs which may reduce thrombotic complications inacute coronary syndromes. The aim of this work was the investigation of the interaction between the phospholipid-GPIIb/IIIa glycoprotein complex ...
Ewa Gorodkiewicz, Anna Sankiewicz, Zbigniew A. Figaszewski   +2 more
doaj  

Emodin Alleviates Sepsis‐Induced Multiorgan Damage by Inhibiting NETosis through Targeting Neutrophils BCL‐10

Advanced Science, EarlyView.
Emodin targets BCL‐10 to modulate the BCL‐10/MALT1 complex, thereby suppressing NF‐κB activation and significantly exerting multiorgan protective effects in sepsis. Abstract Sepsis is a life‐threatening condition caused by dysregulated host responses to infection, characterized by excessive inflammation and abnormal coagulation.
Xiaolong Xu, Yumeng Yan, Meiling Zheng, Mina Zhang, Tengfei Chen, Zhicheng Qu, Yinglu Bai, Shuwen Zhang, Chunming Zhao, Yifan Shi, Yan Lin, Ning Wang, Yunjing Bai, Yating Zhai, Zhaofang Bai, Wei Guo, Qingquan Liu   +16 more
wiley   +1 more source

Monkey Platelet Membrane Glycoproteins and Aggregation

Japanese Journal of Thrombosis and Hemostasis, 1991
The monkey is classified as close to the human and is important as an experimental animal. The present study, a comparison of human and monkey platelet membrane glycopreteins and aggregation, was undertaken.The major platelet membrane glycoprotein was similarly represented in humans and monkeys by SDS-polyacrylamide gel electrophoresis and PAS staining.
Terutoshi Kokawa, Tetsuji Soga, Mutsumasa Yanabu, Naoaki Sone, Koji Iwata, Hirokazu Nagata, Toshihiro Kawakatsu, Shosaku Nomura, Kojiro Yasunaga, Masahiko Suzuki   +9 more
openaire   +2 more sources

Studies on platelet membrane glycoproteins and platelet function during hemodialysis. [PDF]

Journal of the American Society of Nephrology, 1997
Hemodialysis only partially corrects the defects in platelet function associated with uremia. Platelet contact with the artificial surfaces of the dialysis filter during hemodialysis can itself cause platelet activation, degranulation, and loss of platelet membrane glycoproteins.
J A Sloand, E M Sloand
openaire   +3 more sources

Targeting Multilayered Metabolic Networks in Brain Diseases: Emerging Perspectives on Nanodelivery Strategies

Advanced Science, EarlyView.
Brain diseases involve multilayered metabolic disruptions that reshape cellular interactions and microenvironments. This review outlines core metabolic features across disease states and presents emerging nanodelivery strategies as precision tools to reprogram pathological metabolism.
Jingyi Zhou, Chen Jiang
wiley   +1 more source

Mechanical Cues Regulate Cargo Sorting and Export at the Golgi

Advanced Science, EarlyView.
A pathway is identified linking extracellular matrix stiffness to secretion via Src–FAK–AMPK–GBF1 signaling. Golgi‐localized GBF1 acts as a mechanotransducer whose phosphorylation controls post‐Golgi cargo sorting toward secretion or lysosomal degradation.
Greta Serafino, Stefania Forciniti, Edoardo Scarpa, Antonio Ranieri, Lucia Santorelli, Gabriella De Blasi, Sara Costantini, Eunjoo Jun Lee, Antonio Galeone, Alessia Calcagnì, Marinella Pirozzi, Loretta L. del Mercato, Rossella Venditti, Giovanni D'Angelo, Seetharaman Parashuraman, Tiziano Verri, Giuseppe Gigli, Elizabeth S. Sztul, Paolo Grumati, Loris Rizzello, Domenico Russo, Riccardo Rizzo   +21 more
wiley   +1 more source

A fibronectin-binding glycoprotein from human platelet membranes [PDF]

Biochemical Journal, 1981
Fibronectin (‘cold-insoluble globulin’) has been suggested as a possible mediator of platelet adhesion. A fibronectin-binding protein as partially purified from washed solubilized human platelet membranes by affinity chromatography on fibronectin-Sepharose.
M. Sandbjerg Hansen, Inge Clemmensen
openaire   +4 more sources

TWF2 Drives Tumor Progression and Sunitinib Resistance in Renal Cell Carcinoma through Hippo Signaling Suppression

Advanced Science, EarlyView.
Twinfilin actin‐binding protein (TWF2) is upregulated in sunitinib‐resistant renal cell carcinoma (RCC) cells, where it interacts with YAP and protects YAP from degradation. Stabilized YAP translocates into the nucleus and activates transcription of target genes, promoting RCC progression and drug resistance.
Liangmin Fu, Wuyuan Liao, Youyan Tan, Hansen Lin, Kun Ye, Xinwei Zhou, Mingjie Lin, Kangbo Huang, Minyu Chen, Jietao Wei, Haoqian Feng, Yuhang Chen, Jinwei Chen, Bohong Guan, Shan Li, Zhengkun Zhang, Anze Yu, Zihao Feng, Lizhen Zhang, Guannan Shu, Jun Lu, Wei Chen, Yihui Pan, Jiefeng Yang, Junhang Luo, Li Luo   +25 more
wiley   +1 more source

Shear Conditioning Promotes Microvascular Endothelial Barrier Resilience in a Human BBB‐on‐a‐Chip Model of Systemic Inflammation Leading to Astrogliosis

Advanced Science, EarlyView.
Physiological flow (0.5 Pa) conditioning promotes resilience of an iPSC‐derived blood–brain barrier endothelium to mild systemic inflammation. In contrast, high “cytokine storm” levels induce barrier breakdown, fibrinogen leakage, and astrocyte activation, reconstituting the two‐hit injury mechanism on‐a‐chip.
Kaihua Chen, Isabelle M. Linares, Michelle A. Trempel, Alexis M. Feidler, Dinindu De Silva, Sami Farajollahi, Jordan Jones, Julia Kuebel, Pelin Kasap, Britta Engelhardt, Jonathan Flax, Vinay V. Abhyankar, Richard E. Waugh, Harris A. Gelbard, Niccolo Terrando, James L. McGrath   +15 more
wiley   +1 more source