Results 91 to 100 of about 91,077,287 (299)

Overcoming Drug Resistance by Paclitaxel Resistance in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
In the murine triple‐negative breast cancer (TNBC) model, chemotherapy effectively increases tumor neoantigen burden (TNB). Here, the study constructs a liposomal nanovaccine using antigens derived from in vitro chemotherapy‐treated paclitaxel‐resistant TNBC 4T1 cells.
Bo Chen, Yangyi Wang, Tingting Li, Changqing Guo, Zhe Xie, Zhixian Zhang, Xinghua Han, Wei Wang, Jian Wang, Xiaopeng Ma, Yuanzeng Min   +10 more
wiley   +1 more source

Comment on: “Evaluation of Neutrophil to Lymphocyte Ratio, Platelet to Lymphocyte Ratio, and Lymphocyte to Monocyte Ratio in Patients with Cellulitis” [PDF]

Revista da Associação Médica Brasileira, 2020
Easily accessible hemogram-derived parameters have gained the attention of physicians recently. These are simple, practical, and economical parameters that were found useful in the prediction of many clinical problems. They are often used as a sign of chronic inflammation. In chronic inflammatory conditions, their levels are elevated.
openaire   +2 more sources

Targeting the NR1D1–IGF2BP2–V‐ATPase Axis With Hybrid Nanovesicles Restores Macrophage Rhythms to Reverse Sepsis‐Induced Immunosuppression

Advanced Science, EarlyView.
Sepsis disrupts immune‐cell rhythms and weakens bacterial clearance. Biomimetic nanovesicles combining erythrocyte and inflammation‐activated macrophage membranes deliver siNR1D1 to dysfunctional macrophages, restoring the NR1D1–IGF2BP2–V‐ATPase pathway, circadian regulation, phagolysosomal acidification, and antimicrobial defense.
Lang Chen, Wenyi Lin, Lang Jiang, Xuehui Gao, Chenyan Yu, Jili Han, Zhenping Liu, Xuefeng Li, Mei He, Chang Li, Qilan Li, Chaoying Song, Jiqian Xu, You Shang   +13 more
wiley   +1 more source

AHR‐Responsive Carbon Dots Orchestrate Skin Wound Healing and Colonic Mucosal Repair via Treg‐Mediated Macrophage Efferocytosis

Advanced Science, EarlyView.
Guided by pharmacophore modeling and molecular docking, aryl hydrocarbon receptor (AHR)‐responsive carbon dots were synthesized. They bind directly to AHR and expand gut‐resident regulatory T (Treg) cells. Treg‐derived C‐C motif chemokine ligand 1 (CCL1) enhances macrophage efferocytosis, creating a pro‐regenetative niche that promotes colonic mucosal ...
Zilu Zhu, Han Zhang, Shuai Lin, Wenqian Zheng, Xin Li, Xiaowei Xu, Ruili Yang   +6 more
wiley   +1 more source

Value of neutrophil to lymphocyte and platelet to lymphocyte ratios in pneumonia

Bratislava Medical Journal, 2017
In our study, we aimed to evaluate neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) in patients with Community-acquired pneumonia (CAP).This is a retrospective study consisting of 114 patients with CAP and 50 control subjects.
O, Kartal, A T, Kartal
openaire   +3 more sources

Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios in Patients with RetinalArtery Occlusion

Journal of Ophthalmic and Vision Research, 2020
Purpose: This study aimed to compare the neutrophil-to-lymphocyte (NLR) and plateletto- lymphocyte (PLR) ratios in patients with retinal artery occlusion (RAO) with those from a healthy control population and to identify the relationship between them.
Mahmut Atum, Gürsoy Alagöz
openaire   +4 more sources

An Injectable Metal‐Drug Supramolecular Condensate Enables Radiosensitization and Systemic Antitumor Immunity for Post‐Surgical Osteosarcoma Therapy

Advanced Science, EarlyView.
This work designed an injectable metal‐drug supramolecular condensate formed from hafnium ions and alendronate (Hf‐ALN) and loaded with the COX‐2 inhibitor celecoxib (CXB) for synergistic radioimmunotherapy of postoperative osteosarcoma. Mechanistically, upon X‐ray irradiation, Hf enhances radiation energy deposition, ROS generation, and DNA damage ...
Tianhua Xiao, Zunlei Gong, Chuke Chen, Hui Yu, Yu Cai, Can Liu, Hongkai Huang, Ying Li, Jinyuan Guan, Le Wang, Chengyun Ning, Guoxin Tan, Lei Zhou   +12 more
wiley   +1 more source

Usefulness of the platelet-to-lymphocyte ratio in predicting long-term cardiovascular mortality in patients with peripheral arterial occlusive disease [PDF]

, 2017
Introduction: Inflammation and increased platelet activation play a crucial role in the initiation and progression of atherosclerosis. Platelet-to-lymphocyte ratio (PLR) has recently been reported as a new independent predictor for major adverse ...
Huseyin Altug Cakmak, Ali Kemal Kalkan, Umit Bulut, Begum Uygur, Ibrahim Faruk Akturk, Ahmet Arif Yalcin, Kursat Oz, Fatih Uzun, Mehmet Erturk   +8 more
core   +1 more source

Data from Platelet-lymphocyte and neutrophil-lymphocyte ratio are prognostic markers for pheochromocytomas and paragangliomas.pdf

, 2023
Platelet-lymphocyte and neutrophil-lymphocyte ratio are prognostic markers for pheochromocytomas and paragangliomas:Supplemental ...
Jing Xie (6666386), Yifan Yang (170387), Tingwei Su (349513), Lei Jiang (73366), Guang Ning (12328375), Hongyuan Zhu (2506513), Xu Zhong (14816494), Luming Wu (11422678), Cui Zhang (11036730), Yan Qi (14839793), Weiwei Zhou (583665), Yiran Jiang (1788679), Lei Ye (12328344)   +12 more
core   +1 more source

Inflammation Unchecked: Concurrent Kawasaki Disease and Stevens‐Johnson Syndrome in an 18‐Month‐Old Child

Arthritis Care &Research, EarlyView.
Catherine Deffendall, Jodi Backalar, Elizabeth Acevedo Zapata, Adriana Della Porta, Lorin Bibb, Tyler Reese, Charlotte M. Brown   +6 more
wiley   +1 more source