Results 51 to 60 of about 133,426 (198)

Enhancing functional platelet release in vivo from in vitro–grown megakaryocytes using small molecule inhibitors

Blood Advances, 2018
: In vitro–grown megakaryocytes for generating platelets may have value in meeting the increasing demand for platelet transfusions. Remaining challenges have included the poor yield and quality of in vitro–generated platelets. We have shown that infusing
Danuta Jarocha, Karen K. Vo, Randolph B. Lyde, Vincent Hayes, Rodney M. Camire, Mortimer Poncz   +5 more
doaj   +1 more source

Non-canonical proteolytic activation of human prothrombin by subtilisin from Bacillus subtilis may shift the procoagulant\ue2\u80\u93anticoagulant equilibrium toward thrombosis [PDF]

, 2017
Blood coagulation is a finely regulated physiological process culminating with the factor Xa (FXa)-mediated conversion of the prothrombin (ProT) zymogen to active -thrombin (T).
Acquasaliente, Laura, Artusi, Ilaria, De Filippis, Vincenzo, Frasson, Roberta, Peterle, Daniele, Pontarollo, Giulia   +5 more
core   +1 more source

Standardization and validation of a conventional high yield platelet-rich plasma preparation protocol

Annals of Medicine & Surgery, 2022
Of late, numerous randomised controlled trials report platelet-rich plasma (PRP) to be ineffective with preparation protocols of low platelet yield despite using expensive commercial PRP kits.This study aims to identify and standardize a preparation protocol for PRP with maximum platelets yield and concentration to obtain favourable results without the
Muthu, Sathish, Krishnan, Anand, Ramanathan, Karthik Raja   +2 more
openaire   +2 more sources

Collection and composition of autologous peripheral blood stem cells graft in patients with acute myeloid leukemia: influence on hematopoietic recovery and outcome [Skupljanje i sastav transplantata autolognih krvotvornih matičnih stanica periferne krvi u bolesnika s akutnom mijeloičnom leukemijom: utjecaj na hematološki oporavak i ishod] [PDF]

, 2010
Hematopoietic stem cell (HSC) transplantation is a standard approach in the treatment of hematological malignant diseases. For the last 15 years the main source of cells for trasplantation have been peripheral blood stem cells (PBSC).
Batinić, Drago, Bojanić, Ines, Dubravčić, Klara, Dušak, Vesna, Golubić-Ćepulić, Branka, Labar, Boris, Mazić, Sanja, Mrsić, Mirando, Nemet, Damir, Raos, Mirela, Sertić, Dubravka, Serventi-Seiwerth, Ranka   +11 more
core  

Platelet-Activating Factor-Induced Reduction in Contact Hypersensitivity Responses Is Mediated by Mast Cells via Cyclooxygenase-2-Dependent Mechanisms [PDF]

, 2018
Platelet-activating factor (PAF) stimulates numerous cell types via activation of the G protein-coupled PAF receptor (PAFR). PAFR activation not only induces acute proinflammatory responses, but it also induces delayed systemic immunosuppressive effects ...
FitzGerald, Garret A., Kaplan, Mark H., Ocana, Jesus A., Pawelzik, Sven-Christian, Romer, Eric, Sahu, Ravi, Travers, Jeffrey B.   +6 more
core   +1 more source

Influence of donor demographics on the platelet yield during plateletpheresis - experience of 1100 procedures at a tertiary-care hospital

Journal of Pathology of Nepal, 2014
Background: Transfusion of plateletpheresis is effective for treating patients with platelet relatedinsufficiencies while limiting recipient’sexposure to platelets from multiple donors.
S Mangwana
doaj   +1 more source

Synthesis, in vitro, and in vivo biological evaluation and molecular docking simulations of chiral alcohol and ether derivatives of the 1,5-diarylpyrrole scaffold as novel anti-inflammatory and analgesic agents. [PDF]

, 2008
Following our previous research on anti-inflammatory drugs (NSAIDs), we report here the synthesis of chiral 1,5-diarylpyrroles derivatives that were characterized for their in vitro inhibitory effects toward cyclooxygenase (COX) isozymes.
ANZELLOTTI P., ANZINI M., BIAVA M., BOTTA M., CIRILLI R., FERRETTI R., FORLI ., GALLINELLA B., GHELARDINI C., GIORDANI A., LA TORRE F., MAKOVEC F., MANETTI F., NORCINI M., PATRIGNANI P., PERGOLA C., POCE G., PORRETTA G. C., ROSSI, ANTONIETTA, SAUTEBIN, LIDIA, SUPINO S.   +20 more
core   +1 more source

A Comparison of Platelet Count and Enrichment Percentages in the Platelet Rich Plasma (PRP) Obtained Following Preparation by Three Different Methods [PDF]

Journal of Clinical and Diagnostic Research, 2015
Introduction: Platelet rich plasma (PRP) represents an easily accessible and rich source of autologous growth factors. Different manual methods for the preparation of PRP have been suggested.
Ram Sabarish, Vamsi Lavu, Suresh Ranga Rao   +2 more
doaj   +1 more source

Effectiveness of double dose in single donor platelet preparation by the automated blood cell separators in continuous and intermittent flow system

Journal of Associated Medical Sciences, 2016
Background: To prepare single donor platelet (SDP) with good quality and sufficient quantity, beside safety to donors and patients, efficient and less costly automate blood cell separators also be considered.Objectives: To study the double-dose SDP ...
Warangkana Soloslikit, Pichet Vienghok
doaj  

Optimisation of a double-centrifugation method for preparation of canine platelet-rich plasma

BMC Veterinary Research, 2017
Background Platelet-rich plasma (PRP) has been expected for regenerative medicine because of its growth factors. However, there is considerable variability in the recovery and yield of platelets and the concentration of growth factors in PRP preparations.
Hyeok-Soo Shin, Heung-Myong Woo, Byung-Jae Kang   +2 more
doaj   +1 more source