Results 171 to 180 of about 3,387,841 (331)
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
The 3D World of Spheroids: Searching for an Optimal Method of Fabricating Pro-Reparative Cardiospheres. [PDF]
Goltseva Y +7 more
europepmc +1 more source
Ozone Generation by Applying Electrode Tip with Aluminum Plate [PDF]
Siseerot Ketkaew
openalex +1 more source
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Evaluation of five fixation methods for mandibular sagittal split osteotomy in a significant advancement with counterclockwise rotation: a finite element study. [PDF]
Mendes GC +7 more
europepmc +1 more source
USING SYMMETRY TO SOLVE PROBLEMS OF DEFORMATION OF PLATES ON A RIGID FOUNDATION
Oleksii Gurtovyi, S. O. Tynchuk
openalex +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Application of Machine Learning Models in Predicting Vibration Frequencies of Thin Variable Thickness Plates. [PDF]
Domagalski Ł, Kowalczyk I.
europepmc +1 more source
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source

