Results 251 to 260 of about 86,152,617 (312)

Genome‐Wide CRISPR Screen Identifies a microRNA Orchestrating Pleiotropic Resistance to Targeted Therapy and T Cell Immunity in Melanoma

Advanced Science, EarlyView.
A genome‐wide microRNA CRISPR screen identifies miR‐18a as a master regulator of cross‐resistance in melanoma. Loss of miR‐18a activates the AJUBA–YAP/Hippo axis to confer BRAFi resistance and enhances THBS1–CD47 interaction to impair CD8+ T cell immunity. hnRNP A1 is identified as an upstream regulator of miR‐18a processing.
Zhao Wang, Haotian Liu, Xueqi Wang, Jianjin Teng, Zihan Zheng, Jingya Zhang, Wanyi Xiao, Qian Liang, Jiaxin Li, Xiaomeng Jia, Xin Feng, Hongzhang Cui, Menghan Luo, Tielong Yang, Liuxing Wu, Ke Zhao, Weilong Yang, Mulin Jun Li, Dandan Huang, Jilong Yang   +19 more
wiley   +1 more source

Financial Management Innovation in Hospital Groups: An Empirical Study of Ophthalmology Specialty Care Under Consolidation. [PDF]

Risk Manag Healthc Policy
Ye B, Pan X, Wu Z.
europepmc   +1 more source

Machine Learning for Green Solvents: Assessment, Selection and Substitution

Advanced Science, EarlyView.
Environmental regulations have intensified demand for green solvents, but discovery is limited by Solvent Selection Guides (SSGs) that quantify solvent sustainability. Training a machine learning model on GlaxoSmithKline SSG, a database of sustainability metrics for 10,189 solvents, GreenSolventDB is developed. Integrated with Hansen solubility metrics,
Rohan Datta, Janhavi Nistane, Abhishek Sose, Harikrishna Sahu, Rampi Ramprasad   +4 more
wiley   +1 more source

TrainTracks - federated learning for reproducible research on sensitive medical data. [PDF]

BMC Med Inform Decis Mak
Elwes M, Jaberansary M, Tang FK, Aswendt M, Beyan O, Kutafina E.   +5 more
europepmc   +1 more source

Digital-Human Public Community Care Integration for Chronic Pain in Low-Income Older Adults in a 6-Week Living Lab Setting: Quasi-Experimental Feasibility Study. [PDF]

JMIR Aging
Song S, Hwang SY, Kim HY, Kim J.
europepmc   +1 more source

Management Model for the Evaluation of needs and Acquisition of Biomedical Equipment in Healthcare Institutions: Based on WHO Recommendations, and National Regulations. [PDF]

J Med Syst
Villamizar YLQ, Parra LMC, Arevalo FAC, Lozano YAL.   +3 more
europepmc   +1 more source

Evaluation of usability and acceptability of a Peruvian telemental health service for early assessment among vulnerable occupational workers: Mixed-method study with a user-centered design approach. [PDF]

PLoS One
Cainamarks-Alejandro JA, Cruz-Ausejo L, Burgos-Flores MA, Rosales-Rimache J, Astete-Cornejo J, Villarreal-Zegarra D.   +5 more
europepmc   +1 more source

Two-sided dynamics in duopolistic ridesourcing markets with private and pooled rides. [PDF]

NPJ Sustain Mobil Transp
de Ruijter A, Dandl F, Engelhardt R, Bogenberger K, Geržinič N, van Lint H, Cats O.   +6 more
europepmc   +1 more source