Results 81 to 90 of about 282,490 (270)

Enhancing Trusted Cloud Computing Platform for Infrastructure as a Service

Advances in Electrical and Computer Engineering, 2017
The characteristics of cloud computing including on-demand self-service, resource pooling, and rapid elasticity have made it grow in popularity.
KIM, H.
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

CARL: a Complex Applications Interoperability Language based on semantic technologies for platform-as-a-service integration and cloud computing [PDF]

, 2011
Cloud Computing technologies have recently gained momentum and moved from a hyped trend to a mature set of technological innovations providing an infraestructure for the Software-as-a-Service (SaaS) paradigm.
Colomo-Palacios, Ricardo, García-Crespo, Ángel, Gómez-Berbís, Juan Miguel, Jiménez-Domingo, Enrique   +3 more
core   +2 more sources

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Establishment of a coculture system for Porphyromonas gingivalis and head and neck squamous cell carcinoma using spheroid culture and LATS inhibition

FEBS Open Bio, EarlyView.
We established a spheroid coculture system enabling viable Porphyromonas gingivalis–HNSCC interactions under normoxic conditions. Inhibition of LATS1/2 maintains tumor cells in an undifferentiated state, which may promote spheroid growth and create a more permissive environment for bacterial persistence.
Yurika Nakajima, Shogo Okazaki, Muneaki Tamura, Shuichi Sato, Kenichi Imai   +4 more
wiley   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

ECHO: An Adaptive Orchestration Platform for Hybrid Dataflows across Cloud and Edge

, 2017
The Internet of Things (IoT) is offering unprecedented observational data that are used for managing Smart City utilities. Edge and Fog gateway devices are an integral part of IoT deployments to acquire real-time data and enact controls.
Khochare, Aakash, Ravindra, Pushkara, Reddy, Siva Prakash, Sharma, Sarthak, Simmhan, Yogesh, Varshney, Prateeksha   +5 more
core   +1 more source

Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications

FEBS Open Bio, EarlyView.
This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley   +1 more source

Development path of MaaS platforms in China

Journal of Highway and Transportation Research and Development
As urbanization progresses, a novel urban transportation paradigm known as Mobility as a Service (MaaS) has emerged, addressing the principles of environmentally friendly travel and sustainable transport development.
Wenkai Zhan, Zhendong Xie, Zhiguo Dong, Jiehan Yu, Ji Zhao   +4 more
doaj   +1 more source

Building an IoT Platform Based on Service Containerisation. [PDF]

Sensors (Basel), 2021
Antunes M, Santiago AR, Manso S, Regateiro D, Barraca JP, Gomes D, Aguiar RL.   +6 more
europepmc   +1 more source