Results 71 to 80 of about 5,053,101 (285)

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Infrastructure Typology of Metro Stations: A Passenger Simulation Approach Based on Efficiency and Capacity

Applied Sciences
The efficiency of a metro station is determined by the transfer capacity it has on the platform. This is the critical area and the primary motivation for this research. This study analyzed the impact of platform typology on the efficiency and capacity of
Ariel Lopez, Sebastian Seriani, Alvaro Peña, Vicente Aprigliano, Bernardo Arredondo   +4 more
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Big Data Coordination Platform: Full Proposal 2017-2022 [PDF]

, 2016
This proposal for a Big Data and ICT Platform therefore focuses on enhancing CGIAR and partner capacity to deliver big data management, analytics and ICT-focused solutions to CGIAR target geographies and communities.
CGIAR Platform for Big Data in Agriculture
core  

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Construction of network entrepreneurial platform leadership characteristics model: based on the grounded theory

Journal of Business Economics and Management, 2019
With the embedding of internet technology, the entrepreneurial model has been gradually developing from  traditional single linear channel into network platform with symbiotic multi-platform.
Jianlin Pan, Jie Lin
doaj   +1 more source

A Study on Distribution and Characteristics of Radon Concentration in Metro Line 1 in Busan

대한환경공학회지, 2020
Objective:Adverse health effects of Radon with a particular focus on indoor environment has been outlined. Most of the metro stations and platforms are situated under the ground where relatively enhanced concentration of radon has been observed.
Seongwoo Choi, Youngwook Cha, Youngman Cho, Jeonggu Cho   +3 more
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

A Survey of Deep Learning: Platforms, Applications and Emerging Research Trends

IEEE Access, 2018
Deep learning has exploded in the public consciousness, primarily as predictive and analytical products suffuse our world, in the form of numerous human-centered smart-world systems, including targeted advertisements, natural language assistants and ...
William Grant Hatcher, Wei Yu
doaj   +1 more source