Results 31 to 40 of about 120,531,698 (252)
A Systematic Mapping Study of MMOG Backend Architectures
Information, 2019 The advent of utility computing has revolutionized almost every sector of traditionalsoftware development. Especially commercial cloud computing services, pioneered by the likesof Amazon, Google and Microsoft, have provided an unprecedented opportunity ...
Nearchos Paspallis, Nicos Kasenides
doaj +1 more source
A Novel Blockchain-as-a-Service (BaaS) Platform for Local 5G Operators
IEEE Open Journal of the Communications Society, 2021 5G is a promising technology that has the potential to support verticals and applications such as Industrial Internet of Things IoT (IIoT), smart cities, autonomous vehicles, remote surgeries, virtual and augmented realities, and so on.
Nisita Weerasinghe +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy
Molecular Oncology, EarlyView.We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen +19 more
wiley +1 more source
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
, 2021 Denna rapport ingår som en del i projektet ”City As Platform” (CaaP) där vi genom att arbeta med ett gemensamt minimiramverk enkelt ska kunna dela på data samt flytta data-drivna tjänster inom en stad samt mellan städer.
Markendahl, Jan,
core
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Traffic Data Platform based on the Service Oriented Architecture (SOA) [PDF]
, 2010 The DLR Traffic Data Platform (TDP) that is currently being developed by the German Aerospace Center (DLR) is an autonomous decentralised ITS system for distributed intelligent traffic data management and dissemination.
Brockfeld, Elmar +5 more
core +1 more source
Frontiers in Big Data, 2020 Big bibliographic datasets hold promise for revolutionizing the scientific enterprise when combined with state-of-the-science computational capabilities.
Patricia L. Mabry +5 more
doaj +1 more source