Results 141 to 150 of about 54,636 (301)

Science for change: A survey on the normative and political dimensions of global sustainability research

, 2018
Global change and sustainability research increasingly focusses on informing and shaping societal transformations towards more sustainable futures. Doing so, researchers encounter the deeply political and normative dimensions of sustainability problems ...
Global Sustainability Governance, van der Hel, Sandra, Environmental Governance   +2 more
core   +1 more source

Can This Platform Survive? Governance Challenges for the Fediverse

International Journal of Communication
In the wake of recent crises at commercial social media platforms like Twitter and Reddit, the “fediverse” has gained adoption and visibility as a noncommercial alternative for individuals, communities, and institutions to develop channels of public ...
Thomas Struett, Aram Sinnreich, Patricia Aufderheide, Robert W. Gehl   +3 more
doaj  

Fluid Biomarkers of Disease Burden and Cognitive Dysfunction in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Identifying objective biomarkers for progressive supranuclear palsy (PSP) is crucial to improving diagnosis and establishing clinical trial and treatment endpoints. This study evaluated fluid biomarkers in PSP versus controls and their associations with regional 18F‐PI‐2620 tau‐PET, clinical, and cognitive outcomes.
Roxane Dilcher, Charles B. Malpas, Stuart J. McDonald, William T. O’Brien, Craig Despott, Kelly L. Bertram, Matthew P. Pase, Lukas Frontzkowski, Meng Law, Terence J. O’Brien, Lucy Vivash   +10 more
wiley   +1 more source

Antecedents of Reporting Harmful Comments: Testing the Moderating Role of Perceived Transparency

International Journal of Communication
This study examines the antecedents of reporting harmful comments on the platform from a user’s perspective, focusing on perceived media effects. Although some research has examined the “report” or “flag” function as a sociotechnical apparatus for ...
Xinzhou Xie, Zhuo Song, Qiyu Bai
doaj  

Validity of a Wearable Digital Insole for Assessing Gait ON and OFF in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Gait impairment is a distinctive symptom of Parkinson's disease that negatively impact mobility. We assessed the validity of wearable digital insoles against a validated reference gait analysis system for measuring select gait characteristics in patients with Parkinson's disease. Methods A comparative analysis between digital insoles
Deborah A. Hall, Kimberly Kwei, Rolando J. Acosta, Bharatkumar Koyani, Erin Robertson, Pratyush Rai, Roland Barge, Emily Timm, Nicollette L. Purcell, Natasha Desai, Dhanesh Patel, Ana‐Maria Visoiu‐Knapp, Samuel Stuart, Rinol Alaj, Matthew F. Wipperman, Oren Levy, Joan A. O'Keefe   +16 more
wiley   +1 more source

Innate Immune Reprogramming Mediated by Endogenous Retroelement Dysregulation Drives Multiple Sclerosis Progression

Annals of Clinical and Translational Neurology, EarlyView.
Epigenetic reprogramming in hematopoietic stem and progenitor cells (HSPCs) and downstream myeloid cells, mediated by H3.3 downregulation and endogenous retroelement (ERE) overexpression, contributes to the progression of multiple sclerosis (MS). ABSTRACT Background Skewed myelopoiesis in the bone marrow has been identified as a key driver of multiple ...
Li‐Mei Xiao, Qiu‐Ping Zhao, Run‐Yun Li, Wei Chen, Huan‐Huan Song, Wan‐Jin Chen, Ying Fu   +6 more
wiley   +1 more source

CSF Monoamine Metabolites and Cognitive Trajectory in Early Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Imaging and postmortem studies indicate that abnormalities in monoaminergic neurotransmission contribute to cognitive impairment in Parkinson's disease (PD). However, it remains uncertain if cerebrospinal fluid (CSF) monoamine metabolites can serve as biomarkers of cognitive decline in early PD.
Jing‐Yu Shao, Rong Li, Yu‐Xiang Jiao, Kai Ma, Hong‐Qi Yang, Zheng‐Yu Sun, Jie‐Wen Zhang, Shuai Chen   +7 more
wiley   +1 more source

Platform governance mechanisms: An integrated literature review and research directions

, 2020
Firms increasingly harness outside innovation by opening their core product to third parties and thereby shifting towards platform business models.
Halckenhäußer, André, Foerderer, Jens, Heinzl, Armin, Förderer, Jens, Halckenhaeusser, André   +4 more
core  

Prognostic Value of Neurofilament Light Chain and Glial Fibrillary Acidic Protein in ALD‐Related Myelopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background X‐linked adrenoleukodystrophy (X‐ALD) is a neurometabolic disorder caused by pathogenic variants in ABCD1, leading to slowly progressive spinal cord disease in nearly all affected men. Sensitive biomarkers to quantify disease severity and predict progression are needed for clinical care and trial design.
Eda G. Kabak, Marije M. C. Voermans, Hans Heijst, Charlotte E. Teunissen, Marc Engelen   +4 more
wiley   +1 more source

The case for tailor-made digital platform regulation based on platform-governance standard types

The rise of hybrid-conglomerate platforms like Google, Apple, Microsoft, Amazon, and Meta (GAMAM) has led to significant market power concentration and negative competition implications, right down to calls for their potential breakups.
Gleiss, Alexander, Degen, Konrad
core   +1 more source