Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3
ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende +26 more
wiley +1 more source
A self-regulating fhan tracking differentiator algorithm of active disturbance rejection control. [PDF]
Wang Z, Wang X, Bao X.
europepmc +1 more source
ABSTRACT Background Accessing brain magnetic resonance imaging (MRI) can be challenging, especially for underserved patients, which may lead to disparities in neurological diagnosis. Method This mixed‐methods study enrolled adults with one of four neurological disorders: mild cognitive impairment or dementia of the Alzheimer type, multiple sclerosis ...
Maya L. Mastick +19 more
wiley +1 more source
Single-cell transcriptome profile during the antibody decline phase following inactivated COVID-19 vaccination. [PDF]
Zhu Z +8 more
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Objectives Sjögren's disease is an autoimmune disorder that can impact multiple organ systems, including the peripheral nervous system (PNS). PNS manifestations, which can exist concurrently, include mononeuropathies, polyneuropathies, and autonomic nervous system neuropathies. To help patients and providers in the decision‐making process, we developed
Anahita Deboo +19 more
wiley +1 more source
AI medical device post-market surveillance regulations: consensus recommendations by the European Society of Radiology. [PDF]
Cuocolo R +18 more
europepmc +1 more source
This paper proposes two projector‐based Hopfield neural network (HNN) estimators for online, constrained parameter estimation under time‐varying data, additive disturbances, and slowly drifting physical parameters. The first is a constraint‐aware HNN that enforces linear equalities and inequalities (via slack neurons) and continuously tracks the ...
Miguel Pedro Silva
wiley +1 more source
CRISPR-Cas-Mediated Reprogramming Strategies to Overcome Antimicrobial Resistance. [PDF]
Yoon B, Kim JA, Kang YK.
europepmc +1 more source
Bistable Mechanisms 3D Printing for Mechanically Programmable Vibration Control
This work introduces a 3D‐printed bistable mechanism integrated into tuned mass dampers (TMDs) for mechanically adaptive passive vibration suppression. Through optimized geometry, the bistable design provides adaptable vibration reduction across a broad range of scenarios, achieving effective vibration mitigation without complex controls or external ...
Ali Zolfagharian +4 more
wiley +1 more source
From Biocontrol to Synthesis: Innovative Progress of <i>Paenibacillus</i> in Mechanism Analysis, Gene Editing and Platform Construction. [PDF]
Yuan P, Zhu L, Song Z, Wang Y, Chen X.
europepmc +1 more source

