Results 101 to 110 of about 1,147,148 (263)
Molecular Oncology, EarlyView.This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu +3 more
wiley +1 more source
Unregulated Flexibility and the Multiplication of Labour: Work in the Chinese Platform Economy
Social InclusionThe global labour market is witnessing an increase in non‐standard employment, and China is no exception, albeit with distinct socio‐political dynamics.
Jing Wang, Quan Meng
doaj +1 more source
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley +1 more source
Imaginaries of platform work: the platform work directive as a site of discursive friction
Current legal analyses of the Platform Work Directive (PWD) cannot account for the discursive co-construction of platform work. This thesis addresses this gap by examining the PWD as a site of discursive friction where regulatory categories such as “platform,” “worker,” and “employer” are actively contested. Guided by Media and Communications research,
openaire +3 more sources
Gendering Platform Law. An introduction
Labour & Law IssuesEven though the law of digital platforms has been a much-discussed topic in the past few years, academic studies have generally overlooked the gender approach to law and digital technologies. This is hardly surprising. Studies on gender, which have grown
Claire Marzo, Guido Smorto
doaj +1 more source
FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source
Challenging the Myth of AI Autonomy
Weizenbaum Journal of the Digital SocietyA common misconception is that artificial intelligence (AI) functions magically, without human intervention. In reality, AI operates within a socio-technical system reliant on vast amounts of human labor throughout its lifecycle. AI depends on two forms
Uma Rani, Morgan Williams
doaj +1 more source